| Chemical Properties | Back Directory | [Boiling point ]
491.6±55.0 °C(Predicted) | [density ]
1.462±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMSO: 2mg/mL, clear | [form ]
Solid | [pka]
2.45±0.10(Predicted) | [color ]
Yellow to orange | [InChI]
1S/C11H10FN3OS2/c1-2-5-14-11-15-10(13)9(18-11)8(16)6-3-4-7(12)17-6/h2-4H,1,5,13H2,(H,14,15) | [InChIKey]
GVYPHJQPOHDZEI-UHFFFAOYSA-N | [SMILES]
NC1=C(C(C2=CC=C(S2)F)=O)SC(NCC=C)=N1 |
| Hazard Information | Back Directory | [Uses]
TT-10 (TAZ-K) is an activator of YES-associated protein (YAP)-transcriptional enhancer factor domain (TEAD) activity. TT-10 can be used for the research of heart diseases accompanied by cardiomyocyte loss[1]. | [Biological Activity]
TT-10 (TAZ K) is a TAZ (transcriptional coactivator with PDZ-binding motif) activator th at promotes cardiomyocytes (CMs) proliferation (fold-increase by 10 μM TT-10 over untreated control = 5.2/r at CMs/40 hrs & 2.6/human iPSC-derived CMs/48 hrs) by activating YAP (YES-associated protein)/TEAD (transcriptional enhancer factor domain) complex-mediated transcriptionas well as by exerting antioxidant and antiapoptotic activity. TT-10 ameliorates myocardial infarction-induced cardiac dysfunction in mice in vivo (10 mg/kg i.p.) at least in part via enhancing clonal expansion of existing cardiomyocytes with nuclear YAP expression. | [References]
[1] Masamichi Ito, et al. Characterization of a small molecule that promotes cell cycle activation of human induced pluripotent stem cell-derived cardiomyocytes. J Mol Cell Cardiol. 2019 Mar;128:90-95. DOI:10.1016/j.yjmcc.2019.01.020 |
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| Company Name: |
cjbscvictory
|
| Tel: |
13348960310 |
| Website: |
https://www.weikeqi-biotech.com/ |
| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
|