| Identification | Back Directory | [Name]
MAC glucuronide phenol-linked SN-38 | [CAS]
2246380-69-6 | [Synonyms]
MAC glucuronide phenol-linked SN-38 | [Molecular Formula]
C50H54N6O20S | [MDL Number]
MFCD32202364 | [MOL File]
2246380-69-6.mol | [Molecular Weight]
1091.06 |
| Chemical Properties | Back Directory | [Boiling point ]
1395.5±65.0 °C(Predicted) | [density ]
1.63±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
2.77±0.70(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
MAC glucuronide phenol-linked SN-38 is a pH-susceptible lactone MAC glucuronide phenol-linked SN-38 (DNA topoisomerase I inhibitor) agent linker. MAC glucuronide phenol-linked SN-38 is cytotoxic across L540cy cells and Ramos cells with IC50 values of 113 and 67 ng/mL, respectively.Albumin-coupled MAC glucosidol-linked SN-38 shows good stability in mouse plasma[1][2]. | [IC 50]
Camptothecins | [References]
[1] Lau UY, et al. Lactone Stabilization is Not a Necessary Feature for Antibody Conjugates of Camptothecins. Mol Pharm. 2018 Sep 4;15(9):4063-4072. DOI:10.1021/acs.molpharmaceut.8b00477
[2] Lim JH, et al. Evaluation of In Vivo Prepared Albumin-Drug Conjugate Using Immunoprecipitation Linked LC-MS Assay and Its Application to Mouse Pharmacokinetic Study. Molecules. 2023 Apr 4;28(7):3223. DOI:10.3390/molecules28073223 |
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YantaiBio
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13758194781 15083780366 |
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