| Identification | Back Directory | [Name]
β-D-Glucopyranosiduronic acid, 2-[[3-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-1-oxopropyl]amino]-4-(hydroxymethyl)phenyl, methyl ester, 2,3,4-triacetate | [CAS]
894096-02-7 | [Synonyms]
Me-triacetyl-β-D-glucopyranuronate-Ph-CH2OH-Fmoc
β-D-Glucopyranosiduronic acid, 2-[[3-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-1-oxopropyl]amino]-4-(hydroxymethyl)phenyl, methyl ester, 2,3,4-triacetate | [Molecular Formula]
C38H40N2O14 | [MOL File]
894096-02-7.mol | [Molecular Weight]
748.74 |
| Chemical Properties | Back Directory | [Boiling point ]
869.2±65.0 °C(Predicted) | [density ]
1.40±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
11.63±0.46(Predicted) | [color ]
White to light yellow | [InChIKey]
COFWDBMZXNIYIR-SGMQXZHUNA-N | [SMILES]
C(C1C2=CC=CC=C2C2=CC=CC=C12)OC(=O)NCCC(=O)NC1C=C(CO)C=CC=1O[C@@H]1O[C@H](C(=O)OC)[C@@H](OC(=O)C)[C@H](OC(=O)C)[C@H]1OC(=O)C |&1:32,34,39,44,49,r| |
| Hazard Information | Back Directory | [Uses]
Me-triacetyl-β-D-glucopyranuronate-Ph-CH2OH-Fmoc is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. | [IC 50]
Glycosidase Cleavable Linker; Cleavable Linker | [References]
[1] Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337. DOI:10.1038/nrd.2016.268 |
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