| Identification | Back Directory | [Name]
MAC glucuronide linker-2 | [CAS]
229977-57-5 | [Synonyms]
MAC glucuronide linker-2
2-Amino-4-(hydroxymethyl)phenyl methyl 2,3,4-tri-O-acetyl-β-D-glucopyranosiduronate
β-D-Glucopyranosiduronic acid, 2-amino-4-(hydroxymethyl)phenyl, methyl ester, 2,3,4-triacetate
(2S,3R,4S,5S,6S)-2-[2-Amino-4-(hydroxymethyl)phenoxy]-6-(methoxycarbonyl)tetrahydro-2H-pyran-3,4,5-triyl Triacetate | [Molecular Formula]
C20H25NO11 | [MDL Number]
MFCD31715406 | [MOL File]
229977-57-5.mol | [Molecular Weight]
455.41 |
| Chemical Properties | Back Directory | [Boiling point ]
572.5±50.0 °C(Predicted) | [density ]
1.39±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
14.27±0.10(Predicted) | [color ]
White to yellow |
| Hazard Information | Back Directory | [Uses]
MAC glucuronide linker-2 is a cleavable ADC linker for the synthesis of antibody-drug conjugates (ADCs). It contains a methylene alkoxycarbamate (MAC) self-destructive unit and can be used for the targeted delivery of alcohol-containing payloads to ADCs. | [IC 50]
Cleavable Linker; Glycosidase Cleavable Linker |
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