| Identification | Back Directory | [Name]
Benzamide, N-hydroxy-4-[[5-(2-thienyl)-1H-tetrazol-1-yl]methyl]- | [CAS]
2247608-27-9 | [Synonyms]
ITF3756
Benzamide, N-hydroxy-4-[[5-(2-thienyl)-1H-tetrazol-1-yl]methyl]- | [Molecular Formula]
C13H11N5O2S | [MOL File]
2247608-27-9.mol | [Molecular Weight]
301.32 |
| Hazard Information | Back Directory | [Uses]
ITF 3756 is a potent and selective HDAC6 inhibitor. ITF 3756 reduces in vitro the expression of PD-L1 on human monocytes and on CD8 T cells, and shows anti-tumor activity[1]. | [References]
[1] Gianluca Fossati, et al. Abstract 1358: The selective HDAC6 inhibitor ITF3756 stimulates an antitumor immune response and leads to tumor regression in combination with anti CTLA-4 antibody in a colon carcinoma murine model. Cancer Res (2022) 82 (12_Supplement): 1358. |
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