| Identification | Back Directory | [Name]
Benzamide, N-methyl-4-(6-phenylimidazo[1,2-a]pyrazin-3-yl)- | [CAS]
2288709-96-4 | [Synonyms]
N-Methyl-4-(6-phenylimidazo[1,2-a]pyrazin-3-yl)benzamide
Benzamide, N-methyl-4-(6-phenylimidazo[1,2-a]pyrazin-3-yl)- | [Molecular Formula]
C20H16N4O | [MDL Number]
MFCD31715431 | [MOL File]
2288709-96-4.mol | [Molecular Weight]
328.37 |
| Chemical Properties | Back Directory | [density ]
1.25±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: 150 mg/ml | [form ]
A solid | [pka]
14.63±0.46(Predicted) | [color ]
White to off-white | [InChI]
1S/C20H16N4O/c1-21-20(25)16-9-7-15(8-10-16)18-11-23-19-12-22-17(13-24(18)19)14-5-3-2-4-6-14/h2-13H,1H3,(H,21,25) | [InChIKey]
LCRTUEXVVKVKBD-UHFFFAOYSA-N | [SMILES]
[n]21c(ncc2c4ccc(cc4)C(=O)NC)C=NC(=C1)c3ccccc3 |
| Hazard Information | Back Directory | [Uses]
AZ32 is an orally bioavailable and blood-brain barrier-penetrating ATM inhibitor with an IC50 of <6.2 nM for ATM enzyme, and an IC50 of 0.31 μM for ATM in cell. | [Biological Activity]
AZ32 is an oral, blood-brain barrier-penetrating ATM inhibitor with IC50<6.2 nM. Inhibits ATM in cells with IC50 of 0.31 μM. | [in vitro]
AZ32 is a next-generation blood-brain barrier (BBB)-penetrating ATM inhibitor. AZ32 blocks the DNA damage response and radiosensitized GBM cells in vitro. | [in vivo]
AZ32, with enhanced BBB penetration, is highly efficient in vivo as radiosensitizer in syngeneic and human, orthotopic mouse glioma model compared with AZ31. AZ32 is a specific inhibitor of the ATM kinase that possesses good BBB penetration in mouse. Following a single oral dose of AZ32 (200 mg/kg) in mice, the free-brain concentrations of AZ32 are in excess of the cellular IC 50 for approximately 22 hours. | [IC 50]
ATM: 6.2 nM (IC50); ATM: 0.31 μM (IC50, in cell) | [storage]
Store at -20°C | [References]
[1] Karlin J, et al. Orally Bioavailable and Blood-Brain Barrier-Penetrating ATM Inhibitor (AZ32) Radiosensitizes Intracranial Gliomas in Mice. Mol Cancer Ther. 2018 Aug;17(8):1637-1647. DOI:10.1158/1535-7163.MCT-17-0975 |
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| Company Name: |
BOC Sciences
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1-631-485-4226; 16314854226 |
| Website: |
https://www.bocsci.com |
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