| Identification | Back Directory | [Name]
Benzamide, N-methyl-4-(6-phenylimidazo[1,2-a]pyrazin-3-yl)- | [CAS]
2288709-96-4 | [Synonyms]
N-Methyl-4-(6-phenylimidazo[1,2-a]pyrazin-3-yl)benzamide
Benzamide, N-methyl-4-(6-phenylimidazo[1,2-a]pyrazin-3-yl)- | [Molecular Formula]
C20H16N4O | [MDL Number]
MFCD31715431 | [MOL File]
2288709-96-4.mol | [Molecular Weight]
328.37 |
| Hazard Information | Back Directory | [Biological Activity]
AZ32 is an oral, blood-brain barrier-penetrating ATM inhibitor with IC50<6.2 nM. Inhibits ATM in cells with IC50 of 0.31 μM. | [in vitro]
AZ32 is a next-generation blood-brain barrier (BBB)-penetrating ATM inhibitor. AZ32 blocks the DNA damage response and radiosensitized GBM cells in vitro. | [in vivo]
AZ32, with enhanced BBB penetration, is highly efficient in vivo as radiosensitizer in syngeneic and human, orthotopic mouse glioma model compared with AZ31. AZ32 is a specific inhibitor of the ATM kinase that possesses good BBB penetration in mouse. Following a single oral dose of AZ32 (200 mg/kg) in mice, the free-brain concentrations of AZ32 are in excess of the cellular IC 50 for approximately 22 hours. | [storage]
Store at -20°C |
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| Company Name: |
DC Chemicals
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| Tel: |
021-58447131 13564518121 |
| Website: |
https://www.chemicalbook.com/ShowSupplierProductsList927327/0.htm |
| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
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