2288709-96-4
2288709-96-4 结构式
基本信息
Benzamide, N-methyl-4-(6-phenylimidazo[1,2-a]pyrazin-3-yl)-
物理化学性质
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2025/12/22 | HY-112305 | AZ32 | 2288709-96-4 | 1 mg | 365元 |
| 2025/12/22 | HY-112305 | AZ32 AZ32 | 2288709-96-4 | 10 mM * 1 mLin DMSO | 600元 |
| 2025/12/22 | HY-112305 | AZ32 AZ32 | 2288709-96-4 | 5 mg | 830元 |
常见问题列表
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ATM 6.2 nM (IC 50 ) |
ATM 0.31 μM (IC 50 , in cell) |
AZ32 is a next-generation blood-brain barrier (BBB)-penetrating ATM inhibitor. AZ32 blocks the DNA damage response and radiosensitized GBM cells in vitro.
AZ32, with enhanced BBB penetration, is highly efficient in vivo as radiosensitizer in syngeneic and human, orthotopic mouse glioma model compared with AZ31. AZ32 is a specific inhibitor of the ATM kinase that possesses good BBB penetration in mouse. Following a single oral dose of AZ32 (200 mg/kg) in mice, the free-brain concentrations of AZ32 are in excess of the cellular IC 50 for approximately 22 hours.