| Identification | Back Directory | [Name]
(2S,3S,4S,5R,6S)-methyl-6-(2-(3-(((9H-fluoren-9yl)methoxy)carbonyl-amino)propanamido)-4-(((4-nitrophenoxy)carbonyloxy)methyl)phenoxy)-3,4,5-triacetoxy-tetrahydro-2H-pyran-2-carboxylate | [CAS]
894095-98-8 | [Synonyms]
β-D-glucuronide-pNP-carbonate
(2S,3S,4S,5R,6S)-methyl-6-(2-(3-(((9H-fluoren-9yl)methoxy)carbonyl-amino)propanamido)-4-(((4-nitrophenoxy)carbonyloxy)methyl)phenoxy)-3,4,5-triacetoxy-tetrahydro-2H-pyran-2-carboxylate | [Molecular Formula]
C45H43N3O18 | [MDL Number]
MFCD31715405 | [MOL File]
894095-98-8.mol | [Molecular Weight]
913.832 |
| Chemical Properties | Back Directory | [Boiling point ]
982.402±65.00 °C(Press: 760.00 Torr)(predicted) | [density ]
1.458±0.10 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | [form ]
Solid | [pka]
11.633±0.46(predicted) | [color ]
White to off-white | [InChIKey]
DMGQNZOORDYDEZ-DSMMBVICNA-N |
| Hazard Information | Back Directory | [Uses]
β-D-glucuronide-pNP-carbonate is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. | [IC 50]
Glycosidase Cleavable Linker; Cleavable Linker | [References]
[1] Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337. DOI:10.1038/nrd.2016.268 |
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| Company Name: |
Bide Pharmatech Ltd.
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| Telephone: |
400-1647117 13681763483 |
| Website: |
https://www.bidepharm.com/ |
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