| Identification | Back Directory | [Name]
NVS-ZP7-4 | [CAS]
2349367-89-9 | [Synonyms]
NVS-ZP7-4
Spiro[piperidine-4,4'(1'H)-quinazolin]-2'(3'H)-one, 1-[(2S)-2-[(6-fluoro-2-benzothiazolyl)amino]-3-phenylpropyl]- | [EINECS(EC#)]
604-604-1 | [Molecular Formula]
C28H28FN5OS | [MDL Number]
MFCD31813751 | [MOL File]
2349367-89-9.mol | [Molecular Weight]
501.62 |
| Chemical Properties | Back Directory | [storage temp. ]
-20°C, protect from light | [solubility ]
DMSO: soluble; Ethanol: soluble | [form ]
A solid | [color ]
Light yellow to yellow | [InChIKey]
FZOFDZMKSAUTHT-NRFANRHFSA-N | [SMILES]
Fc1cc2[s]c(nc2cc1)N[C@H](CN4CCC5(NC(=O)Nc6c5cccc6)CC4)Cc3ccccc3 |
| Hazard Information | Back Directory | [Uses]
NVS-ZP7-4 is an inhibitor of the zinc transporter SLC39A7 (ZIP7) and indicates ER zinc levels. ZIP7 is an active molecular node in the Notch pathway and mediates ferroptosis. NVS-ZP7-4 induces ER stress and exerts a certain ferroptosis-inhibiting effect, reduces Erastin (HY-15763)-induced cell death[1][2]. | [Biological Activity]
NVS-ZP7-4 is a potent inhibitor of the Notch signaling pathway th at induces endoplasmic reticulum (ER) stress and induces apoptosis in T-ALL cell lines. NVS-ZP7-4 is a potent and selective inhibitor of SLC39A7 (ZIP7) zinc transporter th at increases ER zinc levels. | [References]
[1] Nolin E, et al. Discovery of a ZIP7 inhibitor from a Notch pathway screen. Nat Chem Biol. 2019 Feb;15(2):179-188. DOI:10.1038/s41589-018-0200-7
[2] Chen PH, et al. Zinc transporter ZIP7 is a novel determinant of ferroptosis. Cell Death Dis. 2021 Feb 19;12(2):198. DOI:10.1038/s41419-021-03482-5 |
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