| Identification | Back Directory | [Name]
kaempferol-3-O-galactoside | [CAS]
23627-87-4 | [Synonyms]
Trifolin
Trifolioside
Trifolin【glycoside】
Kaempferol 3-galactoside
kaempferol-3-O-galactoside
kaempferol3-O-β-D-galactoside
Kaempferol 3-galactopyranoside
kaempferol 3-O-beta-D-galactoside
2-(4-Hydroxyphenyl)-3-(β-D-galactopyranosyloxy)-5,7-dihydroxy-4H-1-benzopyran-4-one
3-(β-D-Galactopyranosyloxy)-5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one
4H-1-Benzopyran-4-one,3-(b-D-galactopyranosyloxy)-5,7-dihydroxy-2-(4-hydroxyphenyl)- | [EINECS(EC#)]
200-258-5 | [Molecular Formula]
C21H20O11 | [MDL Number]
MFCD24849351 | [MOL File]
23627-87-4.mol | [Molecular Weight]
448.38 |
| Chemical Properties | Back Directory | [Melting point ]
245-246℃ | [Boiling point ]
823.2±65.0 °C(Predicted) | [density ]
1.79±0.1 g/cm3 (20 ºC 760 Torr) | [storage temp. ]
-20°C | [solubility ]
Ethanol: soluble | [form ]
A solid | [pka]
6.20±0.40(Predicted) | [color ]
Off-white to light yellow |
| Hazard Information | Back Directory | [Uses]
Kaempferol 3-O-β-D-galactopyranoside (Trifolin) is an orally active flavonoid derivative that can be found in the aerial parts of Consolida oliverana. Kaempferol 3-O-β-D-galactopyranoside exhibits antitumor and cardioprotective effects[1][2][3]. | [Definition]
ChEBI: A beta-D-galactoside compound with a 4',5,7-trihydroxychromen-3-yl group at the anomeric position. | [in vivo]
Kaempferol 3-O-β-D-galactopyranoside (0.1–10.0 mg/kg, p.o., once daily for 4 weeks) improves cardiac function and reduces cardiomyocyte apoptosis in Angiotensin II (AngII) (HY-13948)-induced hypertensive cardiac injury C57BL/6 mice model[3]. | Animal Model: | Angiotensin II (AngII) (HY-13948)-induced hypertensive cardiac injury C57BL/6 mice model[3] | | Dosage: | 0.1, 1.0, and 10.0 mg/kg | | Administration: | Oral gavage (p.o.), once daily for 4 weeks | | Result: | Improved left ventricular ejection fraction (LVEF) and fractional shortening (LVFS).
Alleviated inflammatory cell infiltration and pathological damage in cardiac tissue.
Reduced cardiomyocyte apoptosis and regulated Bax, Bcl-2, and cleaved caspase-3 protein expression |
| [storage]
-20°C | [References]
[1] da Silva I, et al. Structure determination of monohydrated trifolin (kaempferol 3-O-β-D-galactopyranoside) from laboratory powder diffraction data. J Pharm Sci. 2011;100(4):1588-1593. DOI:10.1002/jps.22379
[2] Kim MJ, et al. Trifolin induces apoptosis via extrinsic and intrinsic pathways in the NCI-H460 human non-small cell lung-cancer cell line. Phytomedicine. 2016 Sep 15;23(10):998-1004. DOI:10.1016/j.phymed.2016.05.009
[3] Zhang F, et al. Trifolin Attenuates Hypertension-Mediated Cardiac Injury by Inhibiting Cardiomyocyte Apoptosis: Mechanistic Insights and Therapeutic Potential. Eur J Pharmacol. 2024 Nov 9:177125. DOI:10.1016/j.ejphar.2024.177125 |
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