| Identification | Back Directory | [Name]
Fmoc-Gly-Gly-Phe-OtBu | [CAS]
236426-37-2 | [Synonyms]
Fmoc-Gly-Gly-Phe-OtBu
L-Phenylalanine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]glycylglycyl-, 1,1-dimethylethyl ester | [Molecular Formula]
C32H35N3O6 | [MDL Number]
MFCD32689552 | [MOL File]
236426-37-2.mol | [Molecular Weight]
557.64 |
| Chemical Properties | Back Directory | [Boiling point ]
806.7±65.0 °C(Predicted) | [density ]
1.222±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
10.61±0.46(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
Fmoc-Gly-Gly-Phe-OtBu is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. | [IC 50]
Cleavable Linker | [References]
[1] Bak A, et al. Synthesis and evaluation of the physicochemical properties of esterase-sensitive cyclic prodrugs of opioid peptides using an (acyloxy)alkoxy linker. J Pept Res. 1999 Apr;53(4):393-402. DOI:10.1034/j.1399-3011.1999.00070.x |
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