| Identification | Back Directory | [Name]
Benzamide, 4-fluoro-N-methyl-N-[1-[2-(phenylamino)benzoyl]-4-piperidinyl]-2-(trifluoromethyl)- | [CAS]
2376914-71-3 | [Synonyms]
SMO-IN-3
Benzamide, 4-fluoro-N-methyl-N-[1-[2-(phenylamino)benzoyl]-4-piperidinyl]-2-(trifluoromethyl)- | [Molecular Formula]
C27H25F4N3O2 | [MOL File]
2376914-71-3.mol | [Molecular Weight]
499.5 |
| Hazard Information | Back Directory | [Uses]
SMO-IN-3 (compound 12a) is a potent smoothened (SMO) inhibitor with an IC50 value of 34.09 nM for hedgehog (Hh) signaling pathway. SMO-IN-3 has antiproliferative activity against human medulloblastoma cell line Daoy. Anticancer activity[1]. | [References]
[1] Ji D, et al. Design, synthesis and biological evaluation of anthranilamide derivatives as potent SMO inhibitors. Bioorg Med Chem. 2020 Mar 15;28(6):115354. DOI:10.1016/j.bmc.2020.115354 |
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