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2376990-29-1

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2376990-29-1 Structure

2376990-29-1 Structure
IdentificationBack Directory
[Name]

Thalidomide-linker 9
[CAS]

2376990-29-1
[Synonyms]

-ether-alkylC4-amine
Thalidomide-linker 9
Pomalidomide-O-C4-NH2
Thalidomide-O-C4-NH2 hydrochloride
4-(4-Aminobutoxy)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione HCl
4-(4-aminobutoxy)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione hydrochloride
[Molecular Formula]

C17H20ClN3O5
[MDL Number]

MFCD32705123
[MOL File]

2376990-29-1.mol
[Molecular Weight]

381.81
Chemical PropertiesBack Directory
[storage temp. ]

Store at -20°C
[solubility ]

Soluble in DMSO
[form ]

Solid
[color ]

White to light yellow
Hazard InformationBack Directory
[Uses]

Thalidomide-4-O-C4-NH2 hydrochloride is a synthesized?E3 ligase ligand-linker conjugate?that incorporates the Thalidomide (HY-14658) based cereblon ligand and a linker used in PROTAC technology.
[IC 50]

Cereblon
[storage]

Store at -20°C
[References]

[1] Fischer ES, et al. Structure of the DDB1-CRBN E3 ubiquitin ligase in complex with thalidomide. Nature. 2014 Aug 7;512(7512):49-53.??[Content Brief] DOI:10.1038/nature13527
Spectrum DetailBack Directory
[Spectrum Detail]

Thalidomide-linker 9(2376990-29-1)1HNMR
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