| Identification | More | [Name]
2,4,5,6-Tetrafluoroisophthalonitrile | [CAS]
2377-81-3 | [Synonyms]
1,3-Dicyanotetrafluorobenzene
2,4,5,6-TETRAFLUOROBENZENE-1,3-DICARBONITRILE
2,4,5,6-tetrafluoroisophthalonitrile
PERFLUOROISOPHTHALONITRILE
TETRAFLUOROISOPHTHALONITRILE
Tetrafluoroisophthalonitrile,97%
Tetrafluoroisophthalonitrile 98%
Tetrafluoroisophthalonitrile98%
2,4,5,6-Tetrafluoro-1,3-benzenedicarbonitrile | [EINECS(EC#)]
623-653-9 | [Molecular Formula]
C8F4N2 | [MDL Number]
MFCD00013290 | [Molecular Weight]
200.09 | [MOL File]
2377-81-3.mol |
| Chemical Properties | Back Directory | [Appearance]
solid | [Melting point ]
78-79 °C(lit.)
| [Boiling point ]
113-115 °C(Press: 10 Torr) | [density ]
1.6184 (estimate) | [Fp ]
79 °C
| [storage temp. ]
Sealed in dry,Room Temperature | [solubility ]
soluble in Methanol | [form ]
powder to crystal | [color ]
White to Light yellow | [Stability:]
Stability | [BRN ]
6925899 | [InChI]
InChI=1S/C8F4N2/c9-5-3(1-13)6(10)8(12)7(11)4(5)2-14 | [InChIKey]
WVHMPQKZPHOCRD-UHFFFAOYSA-N | [SMILES]
C1(C#N)=C(F)C(F)=C(F)C(C#N)=C1F | [CAS DataBase Reference]
2377-81-3(CAS DataBase Reference) |
| Questions And Answer | Back Directory | [Synthesis]
In a 250 mL three-necked flask, 150 mL of dried sulfolane was added, followed by 26.6 g of dried chlorothalonil. Under mechanical stirring, the mixture was heated to 70 °C to completely dissolve the chlorothalonil. 25.0 g of anhydrous potassium fluoride and 0.5 g of 18-crown ether-6 were quickly added as a phase transfer catalyst. A drying tube was attached to one side of the flask. The reaction was then carried out at 160-180 °C for 8 hours. After cooling to room temperature, the precipitate (KF + KCl) was removed by filtration. The precipitate was washed 2-3 times with 20 mL of sulfolane (approximately 24.9 g in weight). The filtrates were combined and poured into 500 mL of water. The mixture was magnetically stirred for 2 hours. Filtering yielded 17.6 g of precipitate, which was dried and recrystallized from cyclohexane to obtain white needle-like crystals weighing approximately 16.4 g (70.7% yield). |
| Hazard Information | Back Directory | [Chemical Properties]
solid | [Uses]
2,4,5,6-Tetrafluoroisophthalonitrile and derivatives have been used to study their antimicrobial activity against Staphylococcus aureus, Bacillus cereus (Gram-pos. bacteria), Escherichia coli, Pseudomonas aeruginosa (Gram-neg. bacteria); and Candida albicans (Fungi). |
| Spectrum Detail | Back Directory | [Spectrum Detail]
2,4,5,6-Tetrafluoroisophthalonitrile(2377-81-3)MS
2,4,5,6-Tetrafluoroisophthalonitrile(2377-81-3)13CNMR
2,4,5,6-Tetrafluoroisophthalonitrile(2377-81-3)IR1
2,4,5,6-Tetrafluoroisophthalonitrile(2377-81-3)IR2
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| Company Name: |
J & K SCIENTIFIC LTD.
|
| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
Alfa Aesar
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| Telephone: |
400-6106006 |
| Website: |
http://chemicals.thermofisher.cn |
| Company Name: |
Energy Chemical
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| Telephone: |
400-0056266 |
| Website: |
www.energy-chemical.com |
| Company Name: |
China Langchem Inc.
|
| Telephone: |
0086-21-58956006 |
| Website: |
www.chemicalbook.com/ShowSupplierProductsList19141/0_EN.htm |
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