| Identification | Back Directory | [Name]
K-Ras ligand-Linker Conjugate 5 | [CAS]
2378261-85-7 | [Synonyms]
K-Ras ligand-Linker Conjugate 5
1-Piperazinecarboxylic acid, 2-(cyanomethyl)-4-[5,6,7,8-tetrahydro-2-[[(2S,4R)-4-[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethoxy]-1-methyl-2-pyrrolidinyl]methoxy]-7-(1-naphthalenyl)pyrido[3,4-d]pyrimidin-4-yl]-, 1,1-dimethylethyl ester, (2S)- | [Molecular Formula]
C42H59N7O8 | [MDL Number]
MFCD32689634 | [MOL File]
2378261-85-7.mol | [Molecular Weight]
789.96 |
| Chemical Properties | Back Directory | [Boiling point ]
921.7±75.0 °C(Predicted) | [density ]
1.28±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
14.36±0.10(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
K-Ras ligand-Linker Conjugate 5 incorporates a ligand for K-Ras recruiting moiety, and a PROTAC linker, which recruit E3 ligases (such as VHL, CRBN, MDM2, and IAP). K-Ras ligand-Linker Conjugate 5 can be used in the synthesis of PROTAC K-Ras Degrader-1 (HY-129523), which is potent PROTAC K-Ras degrader that exhibits ≥70% degradation efficacy in SW1573 cells[1]. | [References]
[1] CREW, Andrew P., et al. MODULATORS OF PROTEOLYSIS AND ASSOCIATED METHODS OF USE. WO2019195609A2. |
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