| Identification | Back Directory | [Name]
K-Ras ligand-Linker Conjugate 3 | [CAS]
2378261-87-9 | [Synonyms]
K-Ras ligand-Linker Conjugate 3
1-Piperazinecarboxylic acid, 2-(cyanomethyl)-4-[5,6,7,8-tetrahydro-2-[[(2S,4R)-1-methyl-4-[2-[2-[2-[2-[[(4-methylphenyl)sulfonyl]oxy]ethoxy]ethoxy]ethoxy]ethoxy]-2-pyrrolidinyl]methoxy]-7-(1-naphthalenyl)pyrido[3,4-d]pyrimidin-4-yl]-, 1,1-dimethylethyl ester, (2S)- | [Molecular Formula]
C49H65N7O10S | [MDL Number]
MFCD32689597 | [MOL File]
2378261-87-9.mol | [Molecular Weight]
944.15 |
| Chemical Properties | Back Directory | [Boiling point ]
1014.8±75.0 °C(Predicted) | [density ]
1.32±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
7.98±0.60(Predicted) | [color ]
Off-white to light yellow |
| Hazard Information | Back Directory | [Uses]
K-Ras ligand-Linker Conjugate 3 (Compound 001371) incorporates a ligand for K-Ras recruiting moiety, and a PROTAC linker, which recruit E3 ligases (such as VHL, CRBN, MDM2, and IAP). K-Ras ligand-Linker Conjugate 3 can be used in the synthesis of PROTAC K-Ras Degrader-1 (HY-129523), which is potent PROTAC K-Ras degrader that exhibits ≥70% degradation efficacy in SW1573 cells[1]. | [References]
[1] Andrew P. Crew, et al. Modulators of proteolysis and associated methods of use. WO2019195609A2. |
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