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2387510-80-5

2387510-80-5 Structure

2387510-80-5 Structure
IdentificationBack Directory
[Name]

1,4,9-Triazaspiro[5.5]undecane, 4-[3-(3,5-dimethoxyphenyl)-1,2,4-oxadiazol-5-yl]-1-methyl-9-(2-methyl-4-pyridinyl)-
[CAS]

2387510-80-5
[Synonyms]

1,4,9-Triazaspiro[5.5]undecane, 4-[3-(3,5-dimethoxyphenyl)-1,2,4-oxadiazol-5-yl]-1-methyl-9-(2-methyl-4-pyridinyl)-
[Molecular Formula]

C25H32N6O3
[MDL Number]

MFCD32697257
[MOL File]

2387510-80-5.mol
[Molecular Weight]

464.56
Chemical PropertiesBack Directory
[Boiling point ]

654.9±65.0 °C(Predicted)
[density ]

1.29±0.1 g/cm3(Predicted)
[storage temp. ]

2-8°C
[solubility ]

Soluble to 100 mM in DMSO and to 100 mM in 1eq. HCl
[form ]

Solid
[pka]

11.65±0.10(Predicted)
[color ]

White to yellow
Hazard InformationBack Directory
[Description]

MRK-740 is a potent, selective and substrate-competitive PRDM9 histone methyltransferase inhibitor. It is more selective for PRDM9 than other histone methyltransferases and other non-epigenetic targets. MRK-740 reduces PRDM9-dependent trimethylation of H3K4.
[Uses]

MRK-740 is a potent, selective and substrate-competitive PRDM9 histone methyltransferase inhibitor with an IC50 of 80?nM. MRK-740 is more selective for PRDM9 than other histone methyltransferases and other non-epigenetic targets. MRK-740 reduces PRDM9-dependent trimethylation of H3K4 (IC50?=?0.8?μM)[1].
[storage]

Store at -20°C
[References]

[1] Abdellah Allali-Hassani, et al. Discovery of a Chemical Probe for PRDM9. Nat Commun. 2019 Dec 17;10(1):5759. DOI:10.1038/s41467-019-13652-x
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