| Identification | Back Directory | [Name]
PROTAC BRD4 Degrader-5 | [CAS]
2409538-70-9 | [Synonyms]
PROTAC BRD4 Degrader-5 | [Molecular Formula]
C50H62ClN9O8S2 | [MDL Number]
MFCD32874124 | [Molecular Weight]
1016.67 |
| Chemical Properties | Back Directory | [density ]
1.38±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: 145 mg/mL (142.62 mM) | [form ]
Solid | [pka]
13.54±0.46(Predicted) | [color ]
White to off-white | [Water Solubility ]
Water: < 0.1 mg/mL (insoluble) |
| Hazard Information | Back Directory | [Uses]
PROTAC BRD4 Degrader-5 is a PROTAC connected by ligands for von Hippel-Lindau and BRD4. PROTAC BRD4 Degrader-5 can potent degrade BRD4 in HER2 positive and negative breast cancer cell lines[1]. | [IC 50]
BRD4 | [storage]
Store at -20°C | [References]
[1] Mar? A Maneiro, et al. Antibody-PROTAC Conjugates Enable HER2-Dependent Targeted Protein Degradation of BRD4. ACS Chem Biol. 2020 Jun 19;15(6):1306-1312. DOI:10.1021/acschembio.0c00285 |
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