| Identification | Back Directory | [Name]
Nicotinamide riboside tartrate | [CAS]
2415657-86-0 | [Synonyms]
Nicotinamide riboside tartrate | [Molecular Formula]
C15H20N2O11 | [MDL Number]
MFCD34470509 | [MOL File]
2415657-86-0.mol | [Molecular Weight]
404.33 |
| Chemical Properties | Back Directory | [InChIKey]
TXLSDIXNZRLFCH-TUYXCLBSNA-N | [SMILES]
O[C@@H]1[C@@H]([C@@H](CO)O[C@H]1[N+]1=CC=CC(C(=O)N)=C1)O.[C@H](O)(C(=O)[O-])[C@@H](O)C(=O)O |&1:1,2,3,7,18,23,r| |
| Hazard Information | Back Directory | [Uses]
Nicotinamide riboside tartrate, an orally active NAD+ precursor, increases NAD+ levels and activates SIRT1 and SIRT3. Nicotinamide riboside tartrate is a source of vitamin B3 (niacin) and enhances oxidative metabolism, protection against high fat diet-induced metabolic abnormalities[1]. Nicotinamide riboside tartrate reduces cognitive deterioration in a transgenic mouse model of Alzheimer’s disease[2]. | [in vivo]
Chronic Nicotinamide riboside tartrate (p.o.; 400 mg/kg/day; for 16 weeks) supplementation increases plasma and intracellular NAD+ content in a tissue-specific manner[1]. | Animal Model: | 10-week-old C57Bl/6J mice[1] | | Dosage: | 400 mg/kg | | Administration: | PO; daily; for 16 weeks | | Result: | Increased plasma and intracellular NAD+ content in a tissue-specific manner.
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| [IC 50]
SIRT1; SIRT3; Human Endogenous Metabolite | [References]
[1] Cantó C, et al. The NAD(+) precursor nicotinamide riboside enhances oxidative metabolism and protectsagainst high-fat diet-induced obesity. Cell Metab. 2012 Jun 6;15(6):838-47. DOI:10.1016/j.cmet.2012.04.022
[2] Bing Gong, et al. Nicotinamide Riboside Restores Cognition Through an Upregulation of Proliferator-Activated Receptor-γ Coactivator 1α Regulated β-Secretase 1 Degradation and Mitochondrial Gene Expression in Alzheimer's Mouse Models. Neurobiol Aging. 2013 Jun;34(6):1581-8. DOI:10.1016/j.neurobiolaging.2012.12.005
[3] Collin D Heer, et al. Coronavirus and PARP Expression Dysregulate the NAD Metabolome: A Potentially Actionable Component of Innate Immunity. bioRxiv. 2020 Apr 30;2020.04.17.047480. DOI:10.1101/2020.04.17.047480 |
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| Company Name: |
Jiangsu Enzymatic Co.,Ltd.
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| Tel: |
0512-58587898 13812862084 |
| Website: |
https://www.chemicalbook.com/ShowSupplierProductsList1264782/0_EN.htm |
| Company Name: |
MedChemExpress
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| Tel: |
021-58955995 |
| Website: |
www.medchemexpress.com |
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