| Identification | Back Directory | [Name]
Nicotinamide riboside malate | [CAS]
2415659-01-5 | [Synonyms]
Nicotinamide riboside malate
Nicotinamide Riboside Hydrogen Malate | [MDL Number]
MFCD34549739 |
| Hazard Information | Back Directory | [Description]
As a NAD+ precursor, Nicotinamide riboside malate increases NAD+ levels in the body. NAD+ plays an important role in physiological processes such as cellular energy metabolism and DNA repair, and its increased levels help support heart, brain and metabolic function. | [Uses]
Nicotinamide riboside malate, an orally active NAD+ precursor, increases NAD+ levels and activates SIRT1 and SIRT3. Nicotinamide riboside malate is a source of vitamin B3 (niacin) and enhances oxidative metabolism, protection against high fat diet-induced metabolic abnormalities[1]. Nicotinamide riboside malate reduces cognitive deterioration in a transgenic mouse model of Alzheimer’s disease[2]. | [in vivo]
Chronic Nicotinamide riboside malate (p.o.; 400 mg/kg/day; for 16 weeks) supplementation increases plasma and intracellular NAD+ content in a tissue-specific manner[1]. | Animal Model: | 10-week-old C57Bl/6J mice[1] | | Dosage: | 400 mg/kg | | Administration: | PO; daily; for 16 weeks | | Result: | Increased plasma and intracellular NAD+ content in a tissue-specific manner.
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| [IC 50]
SIRT1; SIRT3; Human Endogenous Metabolite | [Advantages]
Nicotinamide riboside malate (NRHM) exhibits superior absorption compared to other forms of NR. Pure NR is sensitive to light and moisture and has poor stability, while Nicotinamide riboside malate (NRHM) enhances its stability by binding with maleic acid, making it more readily absorbed by the body. Furthermore, Nicotinamide riboside malate (NRHM) is absorbed faster than crystalline NR. | [References]
[1] Cantó C, et al. The NAD(+) precursor nicotinamide riboside enhances oxidative metabolism and protectsagainst high-fat diet-induced obesity. Cell Metab. 2012 Jun 6;15(6):838-47. DOI:10.1016/j.cmet.2012.04.022
[2] Bing Gong, et al. Nicotinamide Riboside Restores Cognition Through an Upregulation of Proliferator-Activated Receptor-γ Coactivator 1α Regulated β-Secretase 1 Degradation and Mitochondrial Gene Expression in Alzheimer's Mouse Models. Neurobiol Aging. 2013 Jun;34(6):1581-8. DOI:10.1016/j.neurobiolaging.2012.12.005
[3] Collin D Heer, et al. Coronavirus and PARP Expression Dysregulate the NAD Metabolome: A Potentially Actionable Component of Innate Immunity. bioRxiv. 2020 Apr 30;2020.04.17.047480. DOI:10.1101/2020.04.17.047480 |
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