24269-96-3

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24269-96-3 Structure

Identification	Back Directory
[Name] 5-[2-(5-Nitro-2-furanyl)ethenyl]-2-furancarboxylic Acid Methyl Ester
[CAS] 24269-96-3
[Synonyms] βARK1 Inhibitor GRK2 Inhibitor 1 GRK-2 Inhibitor,GRK2 Inhibitor beta-Adrenergic Receptor Kinase 1 Inhibitor Methyl (E)-5-(2-(5-nitrofuran-2-yl)vinyl)furan-2-carboxylate betaARK1 Inhibitor, beta-Adrenergic Receptor Kinase 1 inhibitor 5-[2-(5-Nitro-2-furanyl)ethenyl]-2-furancarboxylic Acid Methyl Ester 2-Furancarboxylic acid, 5-[2-(5-nitro-2-furanyl)ethenyl]-, methyl ester
[Molecular Formula] C12H9NO6
[MDL Number] MFCD00099039
[MOL File] 24269-96-3.mol
[Molecular Weight] 263.2

Chemical Properties	Back Directory
[Melting point ] 139-140 °C
[Boiling point ] 408.4±45.0 °C(Predicted)
[density ] 1.400±0.06 g/cm3(Predicted)
[storage temp. ] Refrigerator
[solubility ] Acetone (Slightly), Methanol (Slightly)
[form ] Solid
[color ] Pale Yellow to Yellow
[Sensitive ] Light Sensitive
[InChI] 1S/C12H9NO6/c1-17-12(14)10-6-4-8(18-10)2-3-9-5-7-11(19-9)13(15)16/h2-7H,1H3/b3-2+
[InChIKey] YDJPHSNZGRVPCK-NSCUHMNNSA-N
[SMILES] [N+](=O)([O-])c1[o]c(cc1)\C=C\c2[o]c(cc2)C(=O)OC

Safety Data	Back Directory
[WGK Germany ] WGK 1
[Storage Class] 11 - Combustible Solids

Hazard Information	Back Directory
[Uses] 5-[2-(5-Nitro-2-furanyl)ethenyl]-2-furancarboxylic Acid Methyl Ester is an inhibitor of G protein-coupled receptor kinase 2. 5-[2-(5-Nitro-2-furanyl)ethenyl]-2-furancarboxylic Acid Methyl Ester was shown to normalize vascular endothelial function in type 2 diabetic mice by improving β-arrestin 2 translocation and ameliorating Akt/eNOS signal dysfunction.
[Biological Activity] Cell permeable: no''Primary Target βARK1 (β-Adrenergic Receptor Kinase 1)''Product does not compete with ATP.''Reversible: no''Target IC50: 126 μM against βARK1 (β-Adrenergic Receptor Kinase 1)

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