| Identification | More | [Name]
2-Bromophenylboronic acid | [CAS]
244205-40-1 | [Synonyms]
2-BROMOBENZENEBORONIC ACID
2-BROMOPHENYLBORONIC ACID
AKOS BRN-0929
O-BROMOPHENYLBORONIC ACID
RARECHEM AH PB 0074
2-Bromobenzeneboronicacid,98%
2-Bromophenylboronic
2-Bromophenylboronic Acid (contains varying amounts of Anhydride) | [EINECS(EC#)]
678-199-4 | [Molecular Formula]
C6H6BBrO2 | [MDL Number]
MFCD01114672 | [Molecular Weight]
200.83 | [MOL File]
244205-40-1.mol |
| Chemical Properties | Back Directory | [Appearance]
White to off-white powder | [Melting point ]
113 °C(lit.) | [Boiling point ]
329.2±44.0 °C(Predicted) | [density ]
1.67±0.1 g/cm3(Predicted) | [storage temp. ]
Refrigerator (+4°C) | [solubility ]
Acetonitrile (Slightly), Chloroform (Slightly), DMSO (Slightly), Methanol (Sparingly) | [form ]
Powder | [pka]
8.25±0.58(Predicted) | [color ]
White to off-white | [Water Solubility ]
Soluble in methanol. Slightly soluble in water. | [BRN ]
8542615 | [InChI]
InChI=1S/C6H6BBrO2/c8-6-4-2-1-3-5(6)7(9)10/h1-4,9-10H | [InChIKey]
PLVCYMZAEQRYHJ-UHFFFAOYSA-N | [SMILES]
B(C1=CC=CC=C1Br)(O)O | [CAS DataBase Reference]
244205-40-1(CAS DataBase Reference) |
| Safety Data | Back Directory | [Symbol(GHS) ]
GHS07 | [Signal word ]
Warning | [Hazard statements ]
H315-H319-H335 | [Precautionary statements ]
P261-P264-P271-P280-P302+P352-P305+P351+P338 | [Hazard Codes ]
Xn,Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin .
R22:Harmful if swallowed. | [Safety Statements ]
S37/39:Wear suitable gloves and eye/face protection .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice . | [WGK Germany ]
3
| [HazardClass ]
IRRITANT | [HS Code ]
29319090 | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| Hazard Information | Back Directory | [Chemical Properties]
White to off-white powder | [Uses]
2-Bromobenzeneboronic acid is a boronic acid derivative that is widely used in organic synthesis for carbon-carbon bond formation. In Suzuki coupling, aryl halides and boronic acid aryl or vinyl esters or boronic acids are coupled using Pd(PPh3)4. | [Application]
2-Bromophenylboronic Acid is used as an inhibitor of the hormone sensitive lipase.
Catalyzes the formation of amide bonds from amines and carboxylic acids.
Used to promote greener amidations of carboxylic acids and amines in catalytic amounts. This technology avoids the requirement of preactivation of the carboxylic acid or use of coupling reagents.
It is also an important intermediate for Organic Light-Emitting Diod ( OLED) . | [Preparation]
2-Bromophenylboronic acid synthesis: take 2-bromoaniline as raw material, synthesize the intermediate 1-Bromo-2-iodobenzene through diazotization and iodination, and then carry out magnesium iodide exchange with isopropylmagnesium bromide to synthesize o-bromophenylmagnesium bromide, It is then subjected to substitution reaction with trimethyl borate to synthesize methyl o-bromophenylboronic acid, and then hydrolyzed to synthesize 2-bromophenylboronic acid. |
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Energy Chemical
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