| Identification | More | [Name]
3-Bromophenylboronic acid | [CAS]
89598-96-9 | [Synonyms]
3-BROMOBENZENEBORONIC ACID
3-BROMOPHENYLBORONIC ACID
AKOS BRN-0083
RARECHEM AH PB 0076
3-Bromophenylboronic
3-Bromobenzeneboronic acid, 98+%
3-Bromophenylboronic Acid (contains varying amounts of Anhydride) | [EINECS(EC#)]
677-281-7 | [Molecular Formula]
C6H6BBrO2 | [MDL Number]
MFCD00239386 | [Molecular Weight]
200.83 | [MOL File]
89598-96-9.mol |
| Chemical Properties | Back Directory | [Appearance]
white to light yellow crystal powder | [Melting point ]
164-168 °C (lit.) | [Boiling point ]
330.5±44.0 °C(Predicted) | [density ]
1.67±0.1 g/cm3(Predicted) | [storage temp. ]
0-6°C | [solubility ]
DMSO (Slightly), Methanol (Slightly) | [form ]
Crystalline Powder | [pka]
7.55±0.10(Predicted) | [color ]
White | [BRN ]
3127104 | [InChI]
InChI=1S/C6H6BBrO2/c8-6-3-1-2-5(4-6)7(9)10/h1-4,9-10H | [InChIKey]
AFSSVCNPDKKSRR-UHFFFAOYSA-N | [SMILES]
B(C1=CC=CC(Br)=C1)(O)O | [CAS DataBase Reference]
89598-96-9(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xn,Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin .
R22:Harmful if swallowed. | [Safety Statements ]
S37/39:Wear suitable gloves and eye/face protection .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice . | [WGK Germany ]
3
| [Hazard Note ]
Irritant | [HazardClass ]
IRRITANT | [HS Code ]
29319099 |
| Hazard Information | Back Directory | [Chemical Properties]
white to light yellow crystal powder | [Uses]
Reactant involved in a variety of organic reactions including:
- Oxidative cross coupling
- Gold salt catalyzed homocoupling
- 1,4-Addition reactions with α,β-unsaturated ketones
- Enantioselective addition reactions
- Suzuki-Miyaura coupling for synthesis of anthranilamide-protected arylboronic acids
- C-H Functionalization of quinones
| [Uses]
Reactant involved in a variety of organic reactions including:• ;Oxidative cross coupling1,2• ;Gold salt catalyzed homocoupling3• ;1,4-Addition reactions with α,β-unsaturated ketones4• ;Enantioselective addition reactions5• ;Suzuki-Miyaura coupling for synthesis of anthranilamide-protected arylboronic acids6• ;C-H Functionalization of quinones7 | [Uses]
suzuki reaction | [Synthesis]
In a 500 mL round bottom flask, 1-bromo-3-iodobenzene (25.0 g, 88 mmol) was dissolved in 200 mL of tetrahydrofuran. The reaction solution was cooled to -78°C under nitrogen protection. n-Butyllithium (60.75 mL, 97 mmol) was slowly added dropwise to the cooled solution over a period of 30 minutes and stirring was continued at the same temperature for 1 hour. Subsequently, trimethyl borate (11 g, 106 mmol) was added dropwise at the same temperature, and then the mixture was gradually warmed to room temperature and stirred overnight. Upon completion of the reaction, 2 equivalents of hydrochloric acid was added dropwise to the reaction solution for acidification and stirring was continued for 1 hour. The reaction mixture was extracted with ethyl acetate, the organic layers were combined and concentrated under reduced pressure. The resulting crystals were dissolved in cold hexane to give Intermediate 11-a (12 g, 67.6% yield). | [References]
[1] Patent: KR2015/130206, 2015, A. Location in patent: Paragraph 0862-0867
[2] Patent: KR2016/13678, 2016, A. Location in patent: Paragraph 0324-0330 |
|
|