| Identification | Back Directory | [Name]
1H-1,2,4-Triazole-3-carboxamide, 1-(3-chloro-4-fluorophenyl)-N-(3,4-dimethoxyphenyl)-5-(3,4,5-trimethoxyphenyl)- | [CAS]
2447587-73-5 | [Synonyms]
VEGFR-2-IN-22
1H-1,2,4-Triazole-3-carboxamide, 1-(3-chloro-4-fluorophenyl)-N-(3,4-dimethoxyphenyl)-5-(3,4,5-trimethoxyphenyl)- | [Molecular Formula]
C26H24ClFN4O6 | [MOL File]
2447587-73-5.mol | [Molecular Weight]
542.94 |
| Hazard Information | Back Directory | [Uses]
VEGFR-2-IN-22 (Compound 25) is a dual VEGFR-2 and β-tubulin polymerization inhibitor with an IC50 of 19.82 nM against VEGFR-2. VEGFR-2-IN-22 induces apoptosis[1]. | [IC 50]
VEGFR2: 19.82 nM (IC50) | [References]
[1] Abdelhameid MK, et al. Design, synthesis, and cytotoxic screening of novel azole derivatives on hepatocellular carcinoma (HepG2 Cells). Bioorg Chem. 2020 Aug;101:103995. DOI:10.1016/j.bioorg.2020.103995 |
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