Back to ChemicalBook Home--->CAS DataBase List--->24729-96-2

24729-96-2

24729-96-2 Structure

24729-96-2 Structure
IdentificationBack Directory
[Name]

Clindamycin phosphate
[CAS]

24729-96-2
[Synonyms]

u28508
dalacinp
U-28508E
Clindets
Dalacin T
Cleocin T
NSC 618653
(2s-trans)-
cleocinphosphate
ANTIBIOTIC U-28508E
CLINDAMYCIN PHOSPHATE
2-(dihydrogenphosphate
Clindamycine phosphate
CLINDAMYCIN 2-PHOSPHATE
CLINDAMYCINISOPROPYLIDENE
ClindaMycin phosphate API
Clindamycin phosphate USP
7(S)-CHLORO-7-DEOXYLINCOMYCIN
Clindamycin Phosphate (250 mg)
Clindamycin Phosphate (125 mg)
Clindamycin Phosphate (300 mg)
7-Epi ClindaMycin Hydrochloride
Clindamycin HCl/Phosphate (DMF)
CLINDAMYCINPHOSPHATE,CRYSTAL,USP
Clindamycin Phosphate (U-28508E)
CLINDAMYCIN 2-DIHYDROGEN PHOSPHATE
Clindamycin phosphate BP98,USP25,EP97
7(s)-chloro-7-deoxylincomycin2-phosphate
Clindaymcin Palmitate hydrochloride USP23
Clindamycin phosphate for system suitability
Clindamycin 2-phosphate,Clindamycin 2-dihydrogen phosphate
CLINDAMYCIN PHOSPHATE/ 7-(S)-CHLORO-7-DEOXY-LINCOMYCIN-2-ORGANIC PHOSPHATE
l-threo-alpha-d-galacto-octapyranoside,methyl7-chloro-6,7,8-trideoxy-6-(((1-m
7(S)-Chloro-7-deoxylincoMycin 2-phosphate, Cleocin phosphate, ClindaMycin phosphate, NSC 618653, U 28508
Methyl 7-chloro-6,7,8-trideoxy-6-[[[(2S)-1-methyl-4β-propyl-2-pyrrolidinyl]carbonyl]amino]-2-O-phosphono-1-thio-L-threo-α-D-galacto-octopyranoside
Methyl 7-Chloro-6,7,8-trideoxy-6-[[[(2S,4R)-1-Methyl-4-propyl-2-pyrrolidinyl] carbonyl]aMino]-1-thio-D-erythro-α-D-galactooctopyranoside Hydrochloride
Methyl 7-chloro-6,7,8-trideoxy-6-trans-(1-methyl-4-propyl-L-2-pyrrolidinecarboxamido)-1-thio-L-threo-α-D-galacto-octopyranoside 2-(dihydrogen phosphate)
Methyl7-chloro-6,7,8-trideoxy-6-(1-methyl-trans-4-propyl-L-2-pyrrolidinecarboxamido)-1-thio-L-threo-alpha-D-galacto-octopyranoside2-(dihydrogenphosphate)
Methyl 7-chloro-6,7,8-trideoxy-6-[[[(2S)-1-methyl-4β-propyl-2α-pyrrolidinyl]carbonyl]amino]-1-thio-L-threo-α-D-galacto-octopyranoside 2-dihydrogen phosphate
methyl 7-chloro-6,7,8-trideoxy-6-(1-methyl-trans-4-propyl-l-2-pyrrolidinecarboxamido)-1-thio-l-threo-alpha-d-galacto-octopyranoside 2-(dihydrogen phosphate)
methyl 7-chloro-6,7,8-trideoxy-6-[[[(2S,4R)-1-methyl-4-propyl-2-pyrrolidinyl]carbonyl]amino]-1-thio-2-(dihydrogen phosphate)- L-threo-α-D-galacto-octopyranoside
L-threo-.alpha.-D-galacto-Octopyranoside, methyl 7-chloro-6,7,8-trideoxy-6-(2S,4R)-1-methyl-4-propyl-2-pyrrolidinylcarbonylamino-1-thio-, 2-(dihydrogen phosphate)
L-threo-α-D-galacto-Octopyranoside, methyl 7-chloro-6,7,8-trideoxy-6-[[[(2S,4R)-1-methyl-4-propyl-2-pyrrolidinyl]carbonyl]amino]-1-thio-, 2-(dihydrogen phosphate)
L-threo-D-galacto-Octopyranoside, methyl 7-chloro-6,7,8-trideoxy-6-(1-methyl-4-propyl-L-2-pyrrolidinecarboxamido)-1-thio-, 2-(dihydrogen phosphate), trans- α- (8CI)
L-threo-α-D-galacto-Octopyranoside, methyl 7-chloro-6,7,8-trideoxy-6-[[(1-methyl-4-propyl-2-pyrrolidinyl)carbonyl]amino]-1-thio-, 2-(dihydrogen phosphate), (2S-trans)-
methyl (2S-trans)-7-chloro-6,7,8-trideoxy-6-[[(1-methyl-4-propyl-2-pyrrolidinyl)carbonyl]amino]-1-thio-L-threo-alpha-D-galacto-octopyranoside, 2-(dihydrogen phosphate)
[EINECS(EC#)]

246-433-0
[Molecular Formula]

C18H34ClN2O8PS
[MDL Number]

MFCD07793328
[MOL File]

24729-96-2.mol
[Molecular Weight]

504.97
Chemical PropertiesBack Directory
[Appearance]

solid
[Melting point ]

114 °C
[Boiling point ]

159°C
[refractive index ]

122 ° (C=1, H2O)
[storage temp. ]

2-8°C
[solubility ]

DMSO: soluble224mg/mL at 25°C
[form ]

solid
[Stability:]

Stable, but store cool. Incompatible with strong oxidizing agents, calcium gluconate, barbiturates, magnesium sulfate, phenytoin, B group sodium vitamins.
[Water Solubility ]

Freely soluble in water
[Merck ]

14,2356
[Contact allergens]

This lincosanide antibiotic is used in topical form for acne, or systemically has been responsible for exanthematous rashes and acute generalized exanthematous pustulosis.
Hazard InformationBack Directory
[Chemical Properties]

solid
[Uses]

A highly water soluble Clindamycin prodrug.
[Uses]

antibacterial
[Uses]

Clindamycin (C580000) impurity in bulk drug.
[Uses]

Clindamycin 2-phosphate is a a salt of clincamycin, a semi-synthetic lincosamide. The salt is prepared by selective phosphorylation of the 2-hydroxy moiety of the sugar of clindamycin. The introduction of the phosphate affords improved solubility for injectable formulations. Like other members of the lincosamide family, clindamycin 2-phosphate is a broad spectrum antibiotic with activity against anaerobic bacteria and protozoans. Clindamycin acts by binding to the 23S ribosomal subunit, blocking protein synthesis.
[Uses]

Clindamycin 2-phosphate is a salt of clindamycin, a semi-synthetic lincosamide. The salt is prepared by selective phosphorylation of the 2-hydroxy moiety of the sugar of clindamycin. The introduction of the phosphate affords improved solubility for injectable formulations. Like other members of the lincosamide family, clindamycin 2-phosphate is a broad spectrum antibiotic with activity against anaerobic bacteria and protozoans. Clindamycin acts by binding to the 23S ribosomal subunit, blocking protein synthesis.
Safety DataBack Directory
[Hazard Codes ]

Xn,Xi
[Risk Statements ]

22-36/37/38
[Safety Statements ]

36-26
[WGK Germany ]

3
[RTECS ]

GF2625000
[HS Code ]

29419000
Raw materials And Preparation ProductsBack Directory
【Raw materials】

Clindamycin
Questions And AnswerBack Directory
[Description]

clindamycin phosphate is a water-soluble ester of the semisynthetic antibiotic produced by a 7 (S)-chloro-substitution of the 7 (R)-hydroxyl group of the parent antibiotic, lincomycin. It is a derivative of lincomycin(a lincosamide). It has primarily bacteriostatic action against Gram-positive aerobes and a wide range of anaerobicbacteria. Doses are expressed in terms of the base: Clindamycin 1g-1.2g clindamycin phosphate.
[Indications]

Clindamycin Phosphate Topical Solution and Clindamycin Phosphate Lotion (Clindamycin Phosphate Topical Suspension USP, 1%) contain clindamycin phosphate, USP, at a concentration equivalent to 10 mg clindamycin per milliliter. Clindamycin Phosphate Gel contains clindamycin phosphate, USP, at a concentration equivalent to 10 mg clindamycin per gram.
Clindamycin Phosphate Topical lotion
Clindamycin Phosphate is indicated for topical application in the treatment of acne vulgaris. In view of the potential for diarrhea, bloody diarrhea and pseudomembranous colitis, the physician should consider whether other agents are more appropriate.
[CLINICAL PHARMACOLOGY]

Although clindamycin phosphate is inactive in vitro, rapid in vivo hydrolysis converts this compound to the antibacterially active clindamycin.
Cross resistance has been demonstrated between clindamycin and lincomycin.
Antagonism has been demonstrated between clindamycin and erythromycin.
Following multiple topical applications of clindamycin phosphate at a concentration equivalent to 10 mg clindamycin per mL in an isopropyl alcohol and water solution, very low levels of clindamycin are present in the serum (0 to 3 ng/mL) and less than 0.2% of the dose is recovered in urine as clindamycin.
Clindamycin activity has been demonstrated in comedones from acne patients. The mean concentration of antibiotic activity in extracted comedones after application of Clindamycin Phosphate Topical Solution for 4 weeks was 597 mcg/g of comedonal material (range 0 to 1,490). Clindamycin in vitro inhibits all Propionibacterium acnes cultures tested (MICs 0.4 mcg/mL). Free fatty acids on the skin surface have been decreased from approximately 14% to 2% following application of clindamycin.
[Pharmacokinetics]

In an open label, parallel group study of 24 patients with acne vulgaris, once-daily topical administration of approximately 3-12 grams/day of clindamycin phosphate gel for five days resulted in peak plasma clindamycin concentrations that were less than 5.5 ng/ml.
Following multiple applications of clindamycin phosphate gel less than 0.04 % of the total dose was excreted in the urine.
[Biological Activity]

Clindamycin 2-phosphate is an aminoglycoside antibiotic that has been used to study the cytoxicity of antibiotics on human cell lines, Bacterial protein synthesis and peptide translation, and the inhibition of human Tyrosyl-DNA Phosphodiesterase.
Clindamycin 2-phosphate is a pharmacological tyrosyl-DNA phosphodiesterase (Tdp1) inhibitor. Clindamycin 2-phosphate can repair DNA topoisomerase I-DNA covalent complexes by hydrolyzing the tyrosyl-DNA bond. It inhibits protein synthesis in bacteria by binding the 50s ribosomal subunit.  
Spectrum of Activity: Gram positive cocci and taxoplasma. Especially active against anaerobic bacteria.
Mode of Action: Inhibits protein synthesis in bacterial by binding the 50s ribosomal subunit.
[Uses]

Clindamycin phosphate is used topically alone or in conjunction with benzoyl peroxide in the treatment of inflammatory acne vulgaris. In weighing the potential benefits of topical clindamycin therapy, the possibility of serious adverse GI effects associated with the drug should be considered. Therapy of acne vulgaris must be individualized and frequently modified depending on the types of acne lesions which predominate and the response to therapy. Topical anti-infectives, including clindamycin, generally are effective in the treatment of mild to moderate inflammatory acne. However, use of topical anti-infectives as monotherapy may lead to bacterial resistance; this resistance is associated with decreased clinical efficacy.Topical clindamycin is particularly useful when used with benzoyl peroxide or topical retinoids. Results of clinical studies indicate that combination therapy results in a reduction in total lesion counts of 50-70%.
[Drug interactions]

Clindamycin has been shown to have neuromuscular blocking properties that may enhance the action of other neuromuscular blocking agents. Therefore it should be used with caution in patients receiving such agents.
[Incompatibilities]

Clindamycin phosphate is incompatible with natural rubber closures. Aminophylline, ampicillin, calcium gluconate, ceftriaxone, ciprofloxacin,doxapram, drotrecogin alfa (activated), fluconazole, magnesium sulfate,phenytoin sodium, ranitidine, tramadol.
24729-96-2 suppliers list
Company Name: Nantong Haigine Pharma Technology Co., Ltd
Tel: 0086-513-86266699
Fax: 0086-513-86855116
Website: https://www.chemicalbook.com/ShowSupplierProductsList1682173/0.htm
Company Name: Amadis Chemical Company Limited
Tel: 0086-571-89925085
Fax: 0086-571-89925065
Website: www.amadischem.com
Company Name: SIMAGCHEM CORP
Tel: +86 13806087780
Fax:
Website: www.simagchem.com
Company Name: Chemwill Asia Co.,Ltd.
Tel: 86-21-51086038
Fax: 86-21-51861608
Website: www.chemwill.com
Company Name: Haihang Industry Co.,Ltd
Tel: 86-531-88032799
Fax: +86 531 8582 1093
Website: www.haihangindustry.com
Company Name: Hebei Guanlang Biotechnology Co., Ltd.
Tel: +8619930501651
Fax: whatsapp: +8619930501651
Website: www.chemicalbook.com/ShowSupplierProductsList31448/0.htm
Company Name: Xiamen AmoyChem Co., Ltd
Tel: +86 592-605 1114
Fax:
Website: www.amoychem.com
Company Name: Hubei xin bonus chemical co. LTD
Tel: 86-13657291602
Fax: 027-59338440
Website: www.chemicalbook.com/ShowSupplierProductsList1549548/0.htm
Company Name: Beijing Yibai Biotechnology Co., Ltd
Tel: 0086-182-6772-3597
Fax:
Website: www.chemicalbook.com/ShowSupplierProductsList187389/0.htm
Company Name: Chongqing Chemdad Co., Ltd
Tel: +86-13650506873
Fax:
Website: www.chemdad.com
Company Name: CONIER CHEM AND PHARMA LIMITED
Tel: 86-18523575427
Fax:
Website: https://www.chemicalbook.com/ShowSupplierProductsList617604/0.htm
Company Name: Qingdao kaimoshi biochemical technology co., ltd.
Tel: +(86) 571 8719 1975
Fax: +(86) 571 8719 1975
Website: www.kaimosi.com
Company Name: PI & PI BIOTECH INC.
Tel: 18371201331
Fax: 020-81716319
Website: www.pipitech.com
Company Name: Henan Tianfu Chemical Co.,Ltd.
Tel: 0371-55170693
Fax: 0371-55170693
Website: www.tianfuchem.net
Company Name: Henan DaKen Chemical CO.,LTD.
Tel: +86-371-55531817
Fax:
Website: www.dakentech.com
Company Name: career henan chemical co
Tel: +86-371-86658258
Fax:
Website: www.coreychem.com/index.html
Company Name: Chembon Pharmaceutical Co., Ltd.
Tel: +86-28-8425-2981
Fax: +86-28-8425-2965
Website: www.chembon.com.cn
Company Name: Hefei TNJ Chemical Industry Co.,Ltd.
Tel: 86-0551-65418684 18949823763
Fax: 86-0551-65418684
Website: www.tnjchem.com
Tags:24729-96-2 Related Product Information
7664-38-2 7779-90-0 74-83-9 121-79-9 78-40-0 105-66-8 18323-44-9 7601-54-9 21462-39-5 143390-89-0 1405-53-4 99-76-3 75-45-6 96-33-3