| Identification | Back Directory | [Name]
5-(3-Aminoprop-1-yn-1-yl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione hydrochloride | [CAS]
2490402-62-3 | [Synonyms]
Thalidomide-5-propargyne-NH2 HCl
Thalidomide-5-propargyne-NH2, HCl salt
5-(3-Aminoprop-1-yn-1-yl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione hydrochloride | [Molecular Formula]
C16H14ClN3O4 | [MDL Number]
MFCD32852525 | [MOL File]
2490402-62-3.mol | [Molecular Weight]
347.76 |
| Hazard Information | Back Directory | [Uses]
Thalidomide-5-propargyne-NH2 hydrochloride is the Thalidomide-based cereblon ligand used in the recruitment of CRBN protein. Thalidomide-5-propargyne-NH2 hydrochloride can be connected to the ligand for protein by a linker to form PROTACs[1]. | [IC 50]
Cereblon | [References]
[1] Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-994. DOI:10.1016/j.stem.2020.07.019 |
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