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2550869-33-3

2550869-33-3 Structure

2550869-33-3 Structure
IdentificationBack Directory
[Name]

Lomtegovimab
[CAS]

2550869-33-3
[Synonyms]

Lomtegovimab
Research Grade Lomtegovimab (DVV00313)
Hazard InformationBack Directory
[Uses]

Lomtegovimab (BI 767551) is a human anti-SARS-COV-2 spike glycoprotein monoclonal antibody. Lomtegovimab binds and neutralizes SARS-CoV-2. Lomtegovimab shows antiviral efficacy. Lomtegovimab has the potential for the research of COVID-19[1][2].
[in vivo]

Lomtegovimab (40 mg/kg; i.p. or i.n.; once; three days before infection) protects hACE2-transduced mice from infection with SARS-CoV-2[2].

Animal Model:BALB/c mice (Ad_ACE2-mCherry)[2]
Dosage:40 mg/kg
Administration:I.p. or I.n.; once; three days before infection
Result:Led to a complete neutralization of infectious SARS-CoV-2 and slightly reduced amounts of viral RNA in the lungs of treated animals.
[References]

[1] Halwe S, et al. Intranasal Administration of a Monoclonal Neutralizing Antibody Protects Mice against SARS-CoV-2 Infection. Viruses. 2021 Jul 29;13(8):1498. DOI:10.3390/v13081498
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