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2581116-22-3

2581116-22-3 Structure

2581116-22-3 Structure
IdentificationBack Directory
[Name]

Benzamide, N-[2-(1,3-dioxolan-2-yl)ethoxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]-
[CAS]

2581116-22-3
[Synonyms]

Benzamide, N-[2-(1,3-dioxolan-2-yl)ethoxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]-
[Molecular Formula]

C18H16F3IN2O4
[MOL File]

2581116-22-3.mol
[Molecular Weight]

508.23
Chemical PropertiesBack Directory
[density ]

1.692±0.06 g/cm3(Predicted)
[storage temp. ]

Store at -20°C
[form ]

Solid
[pka]

-5.11±0.50(Predicted)
[color ]

White to off-white
Hazard InformationBack Directory
[Uses]

PD0325901-O-C2-dioxolane has main portion of MEK inhibitor PD0325901. PD0325901-O-C2-dioxolane and a ligand of VHL or CRBN E3 ligase can be used in the synthesis of MEK1/2 degrader[1].
[Biological Activity]

PD0325901-O-C2-dioxolane has main portion of MEK inhibitor PD0325901. PD0325901-O-C2-dioxolane and a ligand of VHL or CRBN E3 ligase can be used in the synthesis of MEK1/2 degrader[1]. PD0325901 is a non-ATP competitive MEK inhibitor, potently inhibits ERK signaling and proliferation of tumor cells[1].
[IC 50]

MEK1; MEK2
[References]

[1]. Wei J, et al. Discovery of a First-in-Class Mitogen-Activated Protein Kinase Kinase 1/2 Degrader. J Med Chem. 2019;62(23):10897-10911.
2581116-22-3 suppliers list
Company Name: Shanghai Yifei Biotechnology Co. , Ltd.  
Tel: 021-65675885 18964387627
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Company Name: TargetMol Chemicals Inc.  
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Website: https://www.targetmol.cn/
Company Name: Shenzhen Zuoke Biotechnology Co., Ltd.  
Tel: 13532174601
Website: www.chemicalbook.com/ShowSupplierProductsList1018526/0_EN.htm
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