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2585561-36-8

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2585561-36-8 Structure

2585561-36-8 Structure
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[Name]

PROTAC BRD4 Degrader-16
[CAS]

2585561-36-8
[Synonyms]

PROTAC BRD4 Degrader-16
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[Uses]

PROTAC BRD4 Degrader-16 is a potent PROTAC BRD4 Degrader, with IC50 values of 34.58 nM (BRD4 (BD1)) and 40.23 nM (BRD4 (BD2)). PROTAC BRD4 Degrader-16 ignificantly attenuates G2/M progression associated Cyclin B1 expression. PROTAC BRD4 Degrader-16 significantly induces apoptosis in MV-4-11 cells[1].
[References]

[1] Chen J, et al. Adjusted degradation of BRD4 S and BRD4 L based on fine structural modifications of the pyrrolopyridone scaffold. Eur J Med Chem. 2022 Jun 5;236:114259. DOI:10.1016/j.ejmech.2022.114259
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