2630378-05-9

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2630378-05-9 Structure

Identification	Back Directory
[Name] 2-Thiophenecarboxylic acid, 5-[4-(methoxycarbonyl)phenoxy]-4-nitro-, ethyl ester
[CAS] 2630378-05-9
[Synonyms] USP10 inhibitor Wu-5 2-Thiophenecarboxylic acid, 5-[4-(methoxycarbonyl)phenoxy]-4-nitro-, ethyl ester
[Molecular Formula] C15H13NO7S
[MOL File] 2630378-05-9.mol
[Molecular Weight] 351.33

Chemical Properties	Back Directory
[Boiling point ] 491.8±45.0 °C(Predicted)
[density ] 1.385±0.06 g/cm3(Predicted)
[form ] Solid
[color ] Off-white to light yellow

Hazard Information	Back Directory
[Uses] Wu-5 is a USP10 inhibitor that can inhibit FLT3 and AMPK pathways, induce FLT3-ITD degradation and induce apoptosis[1].
[References] [1] Miao Yu, et al. Wu-5, a novel USP10 inhibitor, enhances crenolanib-induced FLT3-ITD-positive AML cell death via inhibiting FLT3 and AMPK pathways. Acta Pharmacol Sin. 2021 Apr;42(4):604-612. DOI:10.1038/s41401-020-0455-x

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