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264609-13-4

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264609-13-4 Structure

264609-13-4 Structure
IdentificationBack Directory
[Name]

Edonentan
[CAS]

264609-13-4
[Synonyms]

Edonentan Hydrate
[Molecular Formula]

C28H34N4O6S
[MDL Number]

MFCD30719563
[MOL File]

264609-13-4.mol
[Molecular Weight]

554.658
Hazard InformationBack Directory
[Uses]

Edonentan (BMS-207940), a selective antagonist of the endothelin A (ETA) receptor, has been proposed for the treatment of congestive heart failure.
[in vivo]

Edonentan (3-10 μmol/kg, orally) blocks big ET-1 pressor responses[1].
Edonentan (BMS 207940) shows improved systemic clearance (Cl) and steady-state volume of distribution (Vss) in comparison to BMS-193884 (HY-19263)[1].

[IC 50]

ETA: 10 pM (Ki)
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264609-13-4 210891-04-6 180384-56-9 1103522-45-7