| Identification | More | [Name]
TOLUENE DIISOCYANATE | [CAS]
26471-62-5 | [Synonyms]
CRESORCINOL DIISOCYANATE
SCURANATE T65
TDI
TDI-80 TYPE 1
TDI-80 TYPE 2
TOLUENE DIISOCYANATE
TOLUENE DIISOCYANATE MONOMER
TOLYLENE DIISOCYANATE
1,3-diisocyanatomethyl-benzen
1,3-diisocyanatomethyl-Benzene
benzene,1,3-diisocyanatomethyl-
benzene,1,3-diisocyanato-methyl-(2,4-and2,6-(80:20)
desmodurt100
diisocyanatedetoluene(melange65:35)
diisocyanatedetoluene(melange80:20)
diisocyanatomethylbenzene
diisocyanatotoluene
isocyanicacid,methyl-m-phenyleneester
methyl-meta-phenylenediisocyanate
methyl-m-phenyleneisocyanate | [EINECS(EC#)]
247-722-4 | [Molecular Formula]
C9H6N2O2 | [MDL Number]
MFCD01778251 | [Molecular Weight]
174.156 | [MOL File]
26471-62-5.mol |
| Chemical Properties | Back Directory | [Appearance]
Toluene diisocyanate is a colorless, yellow, or dark liquid or solid. It has a sweet, fruity, pungent odor. Toluene diisocyanate (technical, 26471-62-5) is an 80: 20 mixture of 2,4-and 2,6-isomers. A solid above 71/F/22℃. The Odor Threshold is 0.4-2.14 ppm. | [Melting point ]
19.5~21.5℃ | [Boiling point ]
247℃ | [density ]
1.22 | [refractive index ]
1.5660 to 1.5700 | [Fp ]
137 °C | [storage temp. ]
Store below +30°C. | [solubility ]
miscible with Ether,Acetone,Benzene | [form ]
clear liquid | [color ]
Colorless to Light yellow | [Odor]
Sharp, pungent odor | [Water Solubility ]
124mg/L at 25℃ | [Contact allergens]
Toluene diisocyanate is a mixture of 2,4-TDI and 2,6-
TDI. It is used in the manufacture of various polyurethane
products: elastic and rigid foams, paints, lacquers,
adhesives, binding agents, synthetics rubbers, and
elastomeric fibers. | [LogP]
3.43 at 22℃ | [CAS DataBase Reference]
26471-62-5(CAS DataBase Reference) | [IARC]
2B (Vol. 39, Sup 7, 71) 1999 | [EPA Substance Registry System]
Toluene diisocyanate (26471-62-5) |
| Safety Data | Back Directory | [Risk Statements ]
R26:Very Toxic by inhalation.
R36/37/38:Irritating to eyes, respiratory system and skin .
R40:Limited evidence of a carcinogenic effect.
R42/43:May cause sensitization by inhalation and skin contact .
R52/53:Harmful to aquatic organisms, may cause long-term adverse effects in the aquatic environment . | [Safety Statements ]
S23:Do not breathe gas/fumes/vapor/spray (appropriate wording to be specified by the manufacturer) .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) . | [RIDADR ]
2078 | [RTECS ]
NQ9490000 | [HazardClass ]
6.1(a) | [PackingGroup ]
II | [HS Code ]
29291090 | [Safety Profile]
Confirmed carcinogen
with experimental carcinogenic and
neoplastigenic data. Poison by inhalation.
Moderately toxic by ingestion. Severe skin
irritant. Human mutation data reported.
Capable of producing severe dermatitis and
bronchal spasm. A common air
contaminant. A flammable liquid when
exposed to heat or flame. Explosive in the
form of vapor when exposed to heat or
flame. To fight fire, use dry chemical, COa.
Potentially violent polymerization reaction
with bases or acyl chlorides. Reaction with
water releases carbon dioxide. Storage in
polyethylene containers is hazardous due to
absorption of water through the plastic.
When heated to decomposition it emits
highly toxic fumes of NOx. See also
IS0CYANATES . | [Hazardous Substances Data]
26471-62-5(Hazardous Substances Data) | [Toxicity]
A designated hazardous waste (EPA). It is a colorless to
yellow solid, melting at about 20°C. TDI and MDI (diphenylmethane diisocyanate) are used in the manufacture of polyurethane foams by reaction with polyhydroxy compounds. These
foams are used for insulation, upholstering, etc. Exposure is
commonly by inhalation of the vapor. Both TDI and MDI can
cause irritation of eyes and mucous membranes, in severe
cases leading to pulmonary edema. Sensitization to TDI is
common and frequently rapid, leading to an allergic reaction
and some loss of lung function. In the United Kingdom, the
threshold limit value is 0.02 ppm for not more than 20 min, or
0.005 ppm for 8 h. |
| Hazard Information | Back Directory | [General Description]
A clear colorless to pale yellow liquid with a pungent odor. Denser than water. Burns, but may be difficult to ignite. Vapors are heavier than air. Vapors irritate the respiratory system. Toxic under prolonged exposure to vapor in low concentrations or short exposure to high concentrations of vapor. Carcinogenic. Produces toxic oxides of nitrogen during combustion. Used to make polyurethane foams and paints. | [Reactivity Profile]
TOLUENE DIISOCYANATE(26471-62-5) is explosive in the form of vapor-air mixture when exposed to heat, flame or sparks. Potentially violent polymerization reaction with strong bases or acyl chlorides. Reaction with aniline may generate enough heat to ignite unreacted portion and surrounding materials. Reaction with water liberates carbon dioxide. Potential explosion if stored in polyethylene containers due to absorption of water through the plastic. Emits toxic fumes of oxides of nitrogen when heated to decomposition[Lewis, 3rd ed., 1993, p. 1251]. | [Air & Water Reactions]
Reaction with water liberates carbon dioxide. | [Potential Exposure]
Toluene diisocyanate is used in the production of polyurethane flexible foams, coatings, paints, and elastomers. It is more widely used than MDI (diphenylmethane diisocyanate). Polyurethanes are formed by the reaction of isocyanates with polyhydroxy compounds. Since the reaction proceeds rapidly at room temperature, the reactants must be mixed in pots or spray guns just before use. These resins can be produced with various physical properties, for example, hard, flexible, semirigid foams; and have found many uses, for example, upholstery padding; thermal insulation; molds, surface coatings; shoe inner soles; and in rubbers, adhesives, paints, and textile finishes. Because of TDI’s high volatility, exposure can occur in all phases of its manufacture and use. MDI has a much lower volatility, and problems generally arise only in spray applications. | [Fire Hazard]
This chemical is combustible. | [First aid]
If this chemical gets into the eyes, remove any contact lenses at once and irrigate immediately for at least 15(100). minutes, occasionally lifting upper and lower lids. Seek medical attention immediately. If this chemical contacts the skin, remove contaminated clothing and wash immediately with soap and water. Seek medical attention immediately. If this chemical has been inhaled, remove from exposure, begin rescue breathing (using universal precautions, including resuscitation mask) if breathing has stopped and CPR if heart action has stopped. Transfer promptly to a medical facility. When this chemical has been swallowed, get medical attention. Give large quantities of water and induce vomiting. Do not make an unconscious person vomit. Medical observation is recommended for 24-48 hours after breathing overexposure, as pulmonary edema may be delayed. As first aid for pneumonitis or pulmonary edema, a doctor or authorized paramedic may consider administering a drug or other inhalation therapy. | [Shipping]
UN2078 Toluene diisocyanate, Hazard Class: 6.1; Labels: 6.1-Poisonous materials. | [Incompatibilities]
May form explosive mixture with air. Isocyanates are highly flammable and reactive with many compounds, even with themselves. Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Reaction with moist air, water or alcohols may form amines and insoluble polyureas and react exothermically, releasing toxic, corrosive or flammable gases, including carbon dioxide; and, at the same time, may generate a violent release of heat increasing the concentration of fumes in the air. Incompatible with amines, aldehydes, alkali metals, ammonia, carboxylic acids, caprolactum, alkaline materials, glycols, ketones, mercaptans, hydrides, organotin catalysts, phenols, strong acids, strong bases, strong reducing agents such as hydrides, urethanes, and ureas. Elevated temperatures or contact with acids, bases, tertiary amines, and acyl-chlorides may cause explosive polymerization. Attacks some plastics, rubber and coatings. Contact with metals may evolve flammable hydrogen gas. May accumulate static electrical charges, and may cause ignition of its vapors. | [Description]
Toluene diisocyanate (TDI) is an aromatic diisocyanate that
is a clear, pale yellow liquid with a sharp, pungent odor,
which is insoluble in water and miscible with most common
organic solvents. TDI (CAS No. 26471-62-5) consists of two
isomers: toluene-2,4-diisocyanate (2,4-TDI) (CAS No. 584-
84-9) and toluene-2,6-diisocyanate (2,6-TDI) (CAS No. 91-
08-7), which is commercially produced in different ratios.
The most common ratio is 80% 2,4-TDI/20% 2,6 TDI. TDI is
widely used and accounted for 34% of the global isocyanate
market in 2000. | [Chemical Properties]
Toluene diisocyanate is a colorless, yellow, or dark liquid or solid. It has a sweet, fruity, pungent odor. Toluene diisocyanate (technical, 26471-62-5) is an 80: 20 mixture of 2,4-and 2,6-isomers. A solid above 71/F/22℃. The Odor Threshold is 0.4-2.14 ppm. | [Waste Disposal]
Consult with environmental regulatory agencies for guidance on acceptable disposal practices. Generators of waste containing this contaminant (≥100 kg/mo) must conform with EPA regulations governing storage, transportation, treatment, and waste disposal. Controlled incineration (oxides of nitrogen are removed from the effluent gas by scrubbers and/or thermal devices). In accordance with 40CFR165, follow recommendations for the disposal of pesticides and pesticide containers. Must be disposed properly by following package label directions or by contacting your local or federal environmental control agency, or by contacting your regional EPA office. | [Uses]
The functional groups in TDI react with hydroxyl groups to
form urethane linkages, which are used in the manufacture of
flexible polyurethane foams for use in furniture, bedding, and
automotive and commercial transportation seating. Other uses
include polyurethane elastomers used in automobile bumper
covers, industrial rollers, sporting footwear, as well as
mechanical goods and coatings (metal, wood, and highperformance
anticorrosion coatings). TDI-based rigid polyurethane
foam is used in household refrigerators and for
residential construction such as sheathing and commercial
roofing. TDI spray-in rigid foam is used as insulation for truck
trailers, railroad freight cars, and overseas cargo containers.
Moisture-curing TDI coatings are used as wood and concrete
sealants and floor finishes. | [Uses]
Toluene diisocyanates are used primarily to manufacture flexible polyurethane foams for use in furniture, bedding, and automotive and airline seats. Other, smaller uses are for polyurethane elastomers (for automobile bumper covers, industrial rollers, sport soles and boots, and mechanical goods) and coatings (for automotive refinishing, wood finishes, and high-performance anti-corrosion coatings)(ICIS 2009). Toluene diisocyanate–based rigid polyurethane foam is used in household refrigerators and for residential sheathing or commercial roofing in board or laminate form (IARC 1986). “Pour-inplace” or “spray-in” rigid foam is used as insulation for truck trailers, railroad freight cars, and cargo containers. Polyurethane-modified alkyds contain approximately 6% to 7% isocyanate, mostly toluene diisocyanates, and are used as coating materials, such as floor finishes, wood finishes, and paints. Moisture-curing coatings are used as wood and concrete sealants and floor finishes. Aircraft, truck, and passenger-car coatings often are composed of toluene diisocyanate prepolymer systems. Castable urethane elastomers are used in applications requiring strength, flexibility, and shock absorption, and are resistant to oil, solvents, and ultraviolet radiation. They are used in adhesive and sealant compounds and in automobile parts, shoe soles,rollerskate wheels, pond liners, and blood bags. They are also used inoil fields and mines. Certain elastomer products are produced from the pure 2,4 isomer rather than the 80:20 mixture. | [Flammability and Explosibility]
Nonflammable | [Carcinogenicity]
Toluene diisocyanates are reasonably anticipated to be human carcinogens based on sufficient evidence of carcinogenicity from studies in experimental animals. | [Environmental Fate]
TDI is a synthetic organic chemical. It is a natural derivative
of primary amines with the general formula R–N]C]O
which does not occur naturally in the environment. At room
temperature, it can be a liquid or crystal. It is miscible with
alcohol, diglycol, monoethyl ether, ether, acetone, carbon
tetrachloride, benzene, chlorobenzene, kerosene, and olive
oil; however, it may react violently with alcohol, water, acid,
bases, and strong alkaline materials and tertiary amines and
generate enough heat to self-ignite and release toxic
combustion products. TDI reacts with water and most acids
producing unstable carbonic acids, which subsequently
decarboxylate yielding relatively chemically inert and
insoluble polymeric urea. Studies indicate that hydrolysis is
the dominant process in determining the overall environmental
fate, transport, and bioaccumulation potential
of TDI.
Although their rapid hydrolysis in surface water reduces
persistence and bioaccumulation in the environment, diisocyanates
may be stable long enough to be transported some
distances through the atmosphere and inhaled. Since the
hydrolysis products formed are irritants, there is a potential for
inhalation exposure. The degree stability is a function of
humidity. It is expected that TDI does not bioaccumulate
because the tendency to hydrolyze rapidly makes uptake and accumulation very unlikely. The bioconcentration factor ranges
from 151 to 1183 and the bioaccumulation factor is 380. These
values indicate that TDI has a low potential for bioaccumulation
in aquatic organisms. TDI is expected to hydrolyze
rapidly into its transformation products, making TDI
generally unavailable to aquatic organisms. The highly reactive
properties of diisocyanates are likely to be metabolized/
degraded at rates significant enough to counter any potential
for bioaccumulation or biomagnification. It is anticipated that
TDI released to water will primarily form inert polyureas,
which have the potential to be deposited to sediment, forming
an inert component of the sediment strata. While these polyureas
are persistent, studies have indicated that they pose
virtually no potential for adverse impacts on the aquatic
environment. | [Toxicity evaluation]
TDI is a highly reactive compound. The toxicological properties
of isocyanates are attributed to the –N=C=O group. It is
thought to react vigorously and exothermically with water
forming an unstable carbamic acid that dissociates to form
a primary amine with liberation of CO2. Hence, the primary
amine will react further generating a urea derivative. TDI also
reacts readily with all organic compounds resulting in polymerization.
Such reactions denature proteins, form abnormal
cross-linkages, and generally disorganize the protein resulting
in alteration of its normal function. This reactivity with
proteins can account for its potency as a sensitizing agent. Thus,
more than one reaction may occur in a system at a given time.
The toxic effects of TDI can be attributed to two possible toxic
actions:
1. A primary irritant action on the mucous membranes of the
eyes, and the gastrointestinal and respiratory tracts, and
2. Bronchospasm due to either a pharmacological or an
immunological reaction.
This pharmacological reaction can be attributed to altered
β-adrenergic function or the blockade of the S-adrenergic
system by diminishing the formation of c-AMP after catecholamine
stimulation or perhaps to local histamine release. TDI
may also react with naturally occurring proteins or polysaccharides
to form immunohapten complexes. |
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