2651200-35-8

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2651200-35-8 Structure

Identification	Back Directory
[Name] Pyrazolo[1,5-a]-1,3,5-triazin-4-amine, N-[(6,7-difluoro-1H-benzimidazol-2-yl)methyl]-2-(4-morpholinyl)-8-(trifluoromethyl)-
[CAS] 2651200-35-8
[Synonyms] CDK12-IN-5 Pyrazolo[1,5-a]-1,3,5-triazin-4-amine, N-[(6,7-difluoro-1H-benzimidazol-2-yl)methyl]-2-(4-morpholinyl)-8-(trifluoromethyl)-
[Molecular Formula] C18H15F5N8O
[MOL File] 2651200-35-8.mol
[Molecular Weight] 454.36

Hazard Information	Back Directory
[Uses] CDK12-IN-5, a pyrazolotriazine, is a potent CDK12 inhibitor with an IC50 of 23.9 nM at high ATP (2 mM). CDK12-IN-5 has no effect on CDK2/Cyclin E (IC50=173 μM) and CDK9/Cyclin T1 (IC50=127 μM) at high ATP (2 mM) (WO2021116178A1)[1].
[IC 50] CDK12: 23.9 nM (IC₅₀); CDK2/cyclinE: 173 μM (IC₅₀); CDK9/cyclinT1: 127 μM (IC₅₀)
[References] [1] Kai Thede, et al. Pyrazolotriazines. WO2021116178A1.

Spectrum Detail	Back Directory
[Spectrum Detail] Pyrazolo[1,5-a]-1,3,5-triazin-4-amine, N-[(6,7-difluoro-1H-benzimidazol-2-yl)methyl]-2-(4-morpholinyl)-8-(trifluoromethyl)-(2651200-35-8)¹HNMR

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