| Identification | More | [Name]
2-Pyridylethylamine | [CAS]
2706-56-1 | [Synonyms]
2-(2-AMINOETHYL)PYRIDINE
2-(2-PYRIDYL)ETHYLAMINE
2-aminoethylpyridine
2-(PYRIDIN-2-YL)ETHANAMINE
2-PYRIDIN-2-YL-ETHYLAMINE
2-Pyridineethanamine
2-PYRIDYLETHYLAMINE
RARECHEM AL BW 0258
2-(2-Pyridinyl)ethanamine
2-(beta-Aminoethyl)pyridine
alpha-Pyridylethylamine
Demethylbetahistine
lilly04432
Pyridine, 2-(2-aminoethyl)-
2-pyridineethylamine
2-(2-PYRIDYL)ETHYLAMINE 95+%
2-Pyridin-2-ylethanamin
2-(2-Aminoethyl)pyridine ,98%
2-(2-Pyridyl)ethanamine
Pyridine-2-ethanamine | [EINECS(EC#)]
220-295-1 | [Molecular Formula]
C7H10N2 | [MDL Number]
MFCD00006367 | [Molecular Weight]
122.17 | [MOL File]
2706-56-1.mol |
| Chemical Properties | Back Directory | [Appearance]
clear colorless to yellow liquid | [Melting point ]
198-200 °C(Solv: ethanol (64-17-5)) | [Boiling point ]
92-93 °C12 mm Hg(lit.) | [density ]
1.021 g/mL at 25 °C(lit.)
| [refractive index ]
n20/D 1.536(lit.)
| [Fp ]
213 °F
| [storage temp. ]
under inert gas (nitrogen or Argon) at 2–8 °C | [form ]
Liquid | [pka]
pK1: 4.24(+2);pK2: 9.78(+1) (25°C,μ=0.05) | [color ]
Clear colorless to yellow | [Specific Gravity]
1.021 | [Water Solubility ]
Soluble in water (partly), and most common polar solvent. Insoluble in non-polar solvents, and oils. | [Sensitive ]
Air Sensitive | [Detection Methods]
GC | [BRN ]
111208 | [CAS DataBase Reference]
2706-56-1(CAS DataBase Reference) | [NIST Chemistry Reference]
2-Pyridineethanamine(2706-56-1) | [Storage Precautions]
Air sensitive | [EPA Substance Registry System]
2706-56-1(EPA Substance) |
| Questions And Answer | Back Directory | [Synthesis]
A solution of sodium borohydride (0.26 g, 7.00 mmol) in 30 mL of diethyl ether was added dropwise to a mixture of 2-(cyanomethyl)pyridine (0.80 g, 6.82 mmol) and AlCl3 (0.93 g, 7.00 mmol). The solution was stirred at room temperature for 6 hours. The solvent was removed, and the resulting mixture was extracted with hot isopropyl ether (3 x 30 mL). The organic layers were combined, and the solvent was removed under reduced pressure to give 2-Pyridylethylamine. |
| Safety Data | Back Directory | [Symbol(GHS) ]
GHS07 | [Signal word ]
Warning | [Hazard statements ]
H315-H319-H335 | [Precautionary statements ]
P261-P264-P271-P280-P302+P352-P305+P351+P338 | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin .
R34:Causes burns. | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection . | [RIDADR ]
2735 | [WGK Germany ]
3
| [F ]
10-34 | [TSCA ]
Yes | [HazardClass ]
8 | [PackingGroup ]
III | [HS Code ]
29333990 |
| Hazard Information | Back Directory | [Chemical Properties]
clear colorless to yellow liquid | [Uses]
2-(2-Aminoethyl)pyridine is used as active pharmaceutical ingredients. | [Definition]
ChEBI: An aminoalkylpyridine that is pyridine substituted by a ethanamino group at position 2. | [Biological Activity]
Low doses of histamine or H1R agonist 2-pyridylethylamine (2-PEA) into the knee-joint were found to decrease formalin-induced articular nociception in rats. The pharmacological blockade and neurotoxic ablation of cells expressing neuropeptide Y1 receptor (Y1R) in the spinal cord were able to prevent the antinociceptive effect produced by the intra-articular administration of the histamine H1 receptor (H1R) agonist, 2-pyridylethilamine (2-PEA), in the formalin-induced articular incapacitation in rats[1].
| [References]
[1] Eduardo Souza-Silva. “Intra-articular injection of 2-pyridylethylamine produces spinal NPY-mediated antinociception in the formalin-induced rat knee-joint pain model.” Brain Research 1735 (2020): Article 146757. |
|
| Company Name: |
J & K SCIENTIFIC LTD.
|
| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
Alfa Aesar
|
| Telephone: |
400-6106006 |
| Website: |
http://chemicals.thermofisher.cn |
| Company Name: |
Energy Chemical
|
| Telephone: |
400-0056266 |
| Website: |
www.energy-chemical.com |
|