| Identification | More | [Name]
3-Chloro-4-methylphenyl isocyanate | [CAS]
28479-22-3 | [Synonyms]
3-Chlore-4-methylphenyl isocyanate
3-CHLORO-4-METHYLPHENYL ISOCYANATE
Isocyanato-3-chloro-4-methyl benzene
ISOCYANIC ACID 3-CHLORO-4-METHYLPHENYL ESTER
3-chloro-p-tolyl isocyanate
3-Chloro-4-MethylPhenylIsocynate
2-CHLORO-4-ISOCYANATO-TOLUENE
3-Chlor-p-tolylisocyanat | [EINECS(EC#)]
249-050-7 | [Molecular Formula]
C8H6ClNO | [MDL Number]
MFCD00013858 | [Molecular Weight]
167.59 | [MOL File]
28479-22-3.mol |
| Chemical Properties | Back Directory | [Appearance]
Chloromethyl phenyl isocyanate is a colorless
to yellow liquid or beige, low-melting solid. Acrid odor. | [Melting point ]
20-24℃ | [Boiling point ]
107 °C/3 mmHg (lit.) | [density ]
1.224 g/mL at 25 °C(lit.)
| [vapor pressure ]
13.5Pa at 25℃ | [refractive index ]
n20/D 1.557(lit.)
| [Fp ]
229 °F
| [storage temp. ]
2-8°C | [form ]
Liquid or Low Melting Solid | [color ]
Colorless to yellow | [Sensitive ]
Moisture Sensitive | [BRN ]
2690771 | [InChI]
1S/C8H6ClNO/c1-6-2-3-7(10-5-11)4-8(6)9/h2-4H,1H3 | [InChIKey]
UKTKKMZDESVUEE-UHFFFAOYSA-N | [SMILES]
Cc1ccc(cc1Cl)N=C=O | [LogP]
3.78 | [CAS DataBase Reference]
28479-22-3(CAS DataBase Reference) | [EPA Substance Registry System]
28479-22-3(EPA Substance) |
| Safety Data | Back Directory | [Hazard Codes ]
Xn | [Risk Statements ]
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed .
R36/37/38:Irritating to eyes, respiratory system and skin .
R42:May cause sensitization by inhalation. | [Safety Statements ]
S23:Do not breathe gas/fumes/vapor/spray (appropriate wording to be specified by the manufacturer) .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37:Wear suitable protective clothing and gloves .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) . | [RIDADR ]
UN 2206 6.1/PG 3
| [WGK Germany ]
1
| [TSCA ]
Yes | [REACH Registrations]
Active | [HazardClass ]
6.1 | [PackingGroup ]
II | [HS Code ]
29291090 | [Storage Class]
6.1A - Combustible acute toxic Cat. 1 and 2
very toxic hazardous materials | [Hazard Classifications]
Acute Tox. 2 Inhalation
Acute Tox. 4 Dermal
Acute Tox. 4 Oral
Aquatic Acute 1
Aquatic Chronic 1
Eye Dam. 1
Resp. Sens. 1
Skin Corr. 1B
Skin Sens. 1
STOT SE 3 |
| Hazard Information | Back Directory | [General Description]
A colorless liquid with an acrid odor. Denser than water. Contact may irritate skin, eyes and mucous membranes. Flash point 132°F. Toxic by ingestion, inhalation and skin absorption. Used to make other chemicals. | [Reactivity Profile]
Isocyanates and thioisocyanates, such as 3-CHLORO-4-METHYLPHENYL ISOCYANATE, are incompatible with many classes of compounds, reacting exothermically to release toxic gases. Reactions with amines, aldehydes, alcohols, alkali metals, ketones, mercaptans, strong oxidizers, hydrides, phenols, and peroxides can cause vigorous releases of heat. Acids and bases initiate polymerization reactions in these materials. Some isocyanates react with water to form amines and liberate carbon dioxide. Base-catalysed reactions of isocyanates with alcohols should be carried out in inert solvents. Such reactions in the absence of solvents often occur with explosive violence, [Wischmeyer(1969)]. | [Air & Water Reactions]
Flammable. 3-CHLORO-4-METHYLPHENYL ISOCYANATE(28479-22-3) decomposes in water. Substance will react with water (some violently) releasing flammable, toxic or corrosive gases and runoff. | [Health Hazard]
TOXIC; inhalation, ingestion or contact (skin, eyes) with vapors, dusts or substance may cause severe injury, burns or death. Contact with molten substance may cause severe burns to skin and eyes. Reaction with water or moist air will release toxic, corrosive or flammable gases. Reaction with water may generate much heat that will increase the concentration of fumes in the air. Fire will produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution. | [Potential Exposure]
This material is used in organic
synthesis. | [Fire Hazard]
Combustible material: may burn but does not ignite readily. Substance will react with water (some violently) releasing flammable, toxic or corrosive gases and runoff. When heated, vapors may form explosive mixtures with air: indoors, outdoors and sewers explosion hazards. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapors may travel to source of ignition and flash back. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated or if contaminated with water. | [First aid]
If 3-Chloro-4-methylphenyl isocyanate gets into
the eyes, remove any contact lenses at once and irrigate
immediately for at least 15 minutes, occasionally lifting
upper and lower lids. Seek medical attention immediately.
If this chemical contacts the skin, remove contaminated
clothing and wash immediately with soap and water. Seek
medical attention immediately. If this chemical has been
inhaled, remove from exposure, begin rescue breathing
(using universal precautions, including resuscitation mask)
if breathing has stopped and CPR if heart action has
stopped. Transfer promptly to a medical facility. When this
chemical has been swallowed, get medical attention. Give
large quantities of water and induce vomiting. Do not make
an unconscious person vomit. | [Shipping]
UN22363-Chloro-4-methylphenyl isocyanate,
liquid, Hazard Class: 6.1; Labels: 6.1-Poisonous materials. | [Incompatibilities]
May form explosive mixture with air.
Isocyanates are highly flammable and reactive with many
compounds, even with themselves. Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may
cause fires or explosions. Reaction with moist air, water or
alcohols may form amines and insoluble polyureas and
react exothermically, releasing toxic, corrosive, or flammable gases, including carbon dioxide; and, at the same time,
may generate a violent release of heat increasing the concentration of fumes in the air. Incompatible with amines,
aldehydes, alkali metals, ammonia, carboxylic acids, caprolactum, alkaline materials, glycols, ketones, mercaptans,
hydrides, organotin catalysts, phenols, strong acids, strong
bases, strong reducing agents such as hydrides, urethanes,
ureas. Elevated temperatures or contact with acids, bases,
tertiary amines, and acyl-chlorides may cause explosive
polymerization. Attacks some plastics, rubber, and coatings.
Contact with metals may evolve flammable hydrogen gas.
May accumulate static electrical charges, and may cause
ignition of its vapors. Do not store in temperatures above
30C/86F. | [Description]
Chloromethyl phenyl isocyanate is a colorlessto yellow liquid or beige, low-melting solid. Molecularweight =167.59; Melting point =143℃; Vaporpressure =Very low; Flash point ≥ 93℃. Soluble in water;solubility =33 mg/L at 25℃. Insoluble in water | [Chemical Properties]
Chloromethyl phenyl isocyanate is a colorless
to yellow liquid or beige, low-melting solid. Acrid odor. | [Uses]
3-Chloro-4-methylphenyl isocyanate may be used in the synthesis of the following urea compounds:
- 1-(1-(1-adamantyl)methyl)-3-(3-chloro-4-methylphenyl)urea
- 1-(3-chloro-4-methylphenyl)-3-heptylurea
- 1-(3-chloro-4-methylphenyl)-3-cyclooctylurea
- 1-(3-chloro-4-methylphenyl)-3-(3-fluorobenzyl)urea
- 1-(3-chloro-4-methylphenyl)-3-(4-phenylbutan-2-yl)urea
| [storage]
Color Code—Blue: Health Hazard/Poison: Storein a secure poison location. Prior to working with chloromethyl phenyl isocyanate you should be trained on itsproper handling and storage. Chloromethyl phenyl isocyanate must be stored to avoid contact with acids (such ashydrochloric and nitric), alkalis (such as sodium hydroxideand potassium hydroxide), and amines (like ammonia),since violent reactions occur. Store in tightly closedcontainers in a cool, well-ventilated area away from heat,light, and moisture. Do not store at temperatures above30℃/86F. Sources of ignition, such as smoking and openflames, are prohibited where 3-Chloro-4-methyl phenyl isocyanate is used, handled, or stored in a manner that couldcreate a potential fire or explosion hazard |
|
| Company Name: |
Alfa Aesar
|
| Telephone: |
400-6106006 |
| Website: |
http://chemicals.thermofisher.cn |
| Company Name: |
Energy Chemical
|
| Telephone: |
400-0056266 |
| Website: |
www.energy-chemical.com |
| Company Name: |
China Langchem Inc.
|
| Telephone: |
0086-21-58956006 |
| Website: |
www.chemicalbook.com/ShowSupplierProductsList19141/0_EN.htm |
| Company Name: |
Maya High Purity Chemicals
|
| Telephone: |
+86 (573) 82222445 (0)18006601000 452520369 |
| Website: |
www.chemicalbook.com/ShowSupplierProductsList15221/0_EN.htm |
| Company Name: |
Sigma-Aldrich
|
| Telephone: |
021-61415566 800-8193336 |
| Website: |
https://www.sigmaaldrich.cn |
|