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28479-22-3

28479-22-3 Structure

28479-22-3 Structure
IdentificationMore
[Name]

3-Chloro-4-methylphenyl isocyanate
[CAS]

28479-22-3
[Synonyms]

3-Chlore-4-methylphenyl isocyanate
3-CHLORO-4-METHYLPHENYL ISOCYANATE
Isocyanato-3-chloro-4-methyl benzene
ISOCYANIC ACID 3-CHLORO-4-METHYLPHENYL ESTER
3-chloro-p-tolyl isocyanate
3-Chloro-4-MethylPhenylIsocynate
2-CHLORO-4-ISOCYANATO-TOLUENE
3-Chlor-p-tolylisocyanat
[EINECS(EC#)]

249-050-7
[Molecular Formula]

C8H6ClNO
[MDL Number]

MFCD00013858
[Molecular Weight]

167.59
[MOL File]

28479-22-3.mol
Chemical PropertiesBack Directory
[Appearance]

Chloromethyl phenyl isocyanate is a colorless to yellow liquid or beige, low-melting solid. Acrid odor.
[bp ]

107 °C3 mm Hg(lit.)
[density ]

1.224 g/mL at 25 °C(lit.)
[refractive index ]

n20/D 1.557(lit.)
[Fp ]

229 °F
[Sensitive ]

Moisture Sensitive
[BRN ]

2690771
[CAS DataBase Reference]

28479-22-3(CAS DataBase Reference)
[EPA Substance Registry System]

28479-22-3(EPA Substance)
Safety DataBack Directory
[Hazard Codes ]

Xn
[Risk Statements ]

R20/21/22:Harmful by inhalation, in contact with skin and if swallowed .
R36/37/38:Irritating to eyes, respiratory system and skin .
R42:May cause sensitization by inhalation.
[Safety Statements ]

S23:Do not breathe gas/fumes/vapor/spray (appropriate wording to be specified by the manufacturer) .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37:Wear suitable protective clothing and gloves .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
[RIDADR ]

UN 2206 6.1/PG 3
[WGK Germany ]

1
[HazardClass ]

6.1
[PackingGroup ]

II
[HS Code ]

29291090
Hazard InformationBack Directory
[General Description]

A colorless liquid with an acrid odor. Denser than water. Contact may irritate skin, eyes and mucous membranes. Flash point 132°F. Toxic by ingestion, inhalation and skin absorption. Used to make other chemicals.
[Reactivity Profile]

Isocyanates and thioisocyanates, such as 3-CHLORO-4-METHYLPHENYL ISOCYANATE, are incompatible with many classes of compounds, reacting exothermically to release toxic gases. Reactions with amines, aldehydes, alcohols, alkali metals, ketones, mercaptans, strong oxidizers, hydrides, phenols, and peroxides can cause vigorous releases of heat. Acids and bases initiate polymerization reactions in these materials. Some isocyanates react with water to form amines and liberate carbon dioxide. Base-catalysed reactions of isocyanates with alcohols should be carried out in inert solvents. Such reactions in the absence of solvents often occur with explosive violence, [Wischmeyer(1969)].
[Air & Water Reactions]

Flammable. 3-CHLORO-4-METHYLPHENYL ISOCYANATE(28479-22-3) decomposes in water. Substance will react with water (some violently) releasing flammable, toxic or corrosive gases and runoff.
[Health Hazard]

TOXIC; inhalation, ingestion or contact (skin, eyes) with vapors, dusts or substance may cause severe injury, burns or death. Contact with molten substance may cause severe burns to skin and eyes. Reaction with water or moist air will release toxic, corrosive or flammable gases. Reaction with water may generate much heat that will increase the concentration of fumes in the air. Fire will produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution.
[Potential Exposure]

This material is used in organic synthesis.
[First aid]

If 3-Chloro-4-methylphenyl isocyanate gets into the eyes, remove any contact lenses at once and irrigate immediately for at least 15 minutes, occasionally lifting upper and lower lids. Seek medical attention immediately. If this chemical contacts the skin, remove contaminated clothing and wash immediately with soap and water. Seek medical attention immediately. If this chemical has been inhaled, remove from exposure, begin rescue breathing (using universal precautions, including resuscitation mask) if breathing has stopped and CPR if heart action has stopped. Transfer promptly to a medical facility. When this chemical has been swallowed, get medical attention. Give large quantities of water and induce vomiting. Do not make an unconscious person vomit.
[Fire Hazard]

Combustible material: may burn but does not ignite readily. Substance will react with water (some violently) releasing flammable, toxic or corrosive gases and runoff. When heated, vapors may form explosive mixtures with air: indoors, outdoors and sewers explosion hazards. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapors may travel to source of ignition and flash back. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated or if contaminated with water.
[Shipping]

UN22363-Chloro-4-methylphenyl isocyanate, liquid, Hazard Class: 6.1; Labels: 6.1-Poisonous materials.
[Incompatibilities]

May form explosive mixture with air. Isocyanates are highly flammable and reactive with many compounds, even with themselves. Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Reaction with moist air, water or alcohols may form amines and insoluble polyureas and react exothermically, releasing toxic, corrosive, or flammable gases, including carbon dioxide; and, at the same time, may generate a violent release of heat increasing the concentration of fumes in the air. Incompatible with amines, aldehydes, alkali metals, ammonia, carboxylic acids, caprolactum, alkaline materials, glycols, ketones, mercaptans, hydrides, organotin catalysts, phenols, strong acids, strong bases, strong reducing agents such as hydrides, urethanes, ureas. Elevated temperatures or contact with acids, bases, tertiary amines, and acyl-chlorides may cause explosive polymerization. Attacks some plastics, rubber, and coatings. Contact with metals may evolve flammable hydrogen gas. May accumulate static electrical charges, and may cause ignition of its vapors. Do not store in temperatures above 30C/86F.
Well-known Reagent Company Product InformationBack Directory
[Alfa Aesar]

3-Chloro-4-methylphenyl isocyanate, 98%(28479-22-3)
[Sigma Aldrich]

28479-22-3(sigmaaldrich)
[TCI AMERICA]

3-Chloro-4-methylphenyl Isocyanate,>97.0%(GC)(28479-22-3)
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