| Identification | Back Directory | [Name]
7-Methoxy-6-benzyloxyquinazolin-4-one | [CAS]
286371-64-0 | [Synonyms]
7-Methoxy-6-benzyloxyquinazolin-4-one
6-Benzyloxy-7-methoxyquinazoline-4-one
6-(benzyloxy)-7-methoxyquinazolin-4-ol
6-Benzyloxy-7-Methoxy-3H-quinazolin-4-one
6-(Benzyloxy)-7-Methoxyquinazolin-4(1H)-one
7-Methoxy-6-(phenylmethoxy)-4(1H)-quinazolinone
4(3H)-Quinazolinone, 7-methoxy-6-(phenylmethoxy)- | [Molecular Formula]
C16H14N2O3 | [MDL Number]
MFCD13185883 | [MOL File]
286371-64-0.mol | [Molecular Weight]
282.29 |
| Chemical Properties | Back Directory | [Melting point ]
252 °C(Solv: methanol (67-56-1)) | [Boiling point ]
475.4±55.0 °C(Predicted) | [density ]
1.26 | [storage temp. ]
Keep in dark place,Inert atmosphere,Room temperature | [pka]
1.43±0.20(Predicted) | [Appearance]
Off-white to gray Solid |
| Hazard Information | Back Directory | [Synthesis]
Synthesis of 6-(benzyloxy)-7-methoxyquinazolin-4(3H)-one: 2-amino-5-(benzyloxy)-4-methoxybenzoic acid (5 g, 18.3 mmol) was mixed with formamidine acetate (3.8 g, 36.6 mmol) in ethylene glycol monomethyl ether (25 mL). The reaction mixture was heated at 130°C for 24 hours. After completion of the reaction, it was cooled to room temperature and concentrated in vacuum to remove some of the solvent. Subsequently, ammonium hydroxide (5 mL, 30% aqueous solution) and water (50 mL) were added. The precipitated solid was collected by filtration, washed with water and hexane, and dried under vacuum to give 4.87 g of 6-benzyloxy-7-methoxyquinazolin-4-one in 94% yield. Mass spectrum (AP/CI): 283.1 (M+H)+. | [References]
[1] Patent: WO2008/20302, 2008, A2. Location in patent: Page/Page column 29
[2] Journal of Medicinal Chemistry, 2011, vol. 54, # 13, p. 4536 - 4547 |
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