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288-14-2

288-14-2 Structure

288-14-2 Structure
IdentificationMore
[Name]

Isoxazole
[CAS]

288-14-2
[Synonyms]

ISOXAZOLE
1-Oxa-2-azacyclopentadiene
Isooxazole
ISOXAZOLE 98+%
1,2-Oxazole
[EINECS(EC#)]

206-018-7
[Molecular Formula]

C3H3NO
[MDL Number]

MFCD00003149
[Molecular Weight]

69.06
[MOL File]

288-14-2.mol
Chemical PropertiesBack Directory
[Appearance]

Colorless liquid
[bp ]

93-95 °C(lit.)
[density ]

1.078 g/mL at 25 °C(lit.)
[vapor density ]

2.4 (vs air)
[refractive index ]

n20/D 1.427(lit.)
[Fp ]

48 °F
[storage temp. ]

Store at RT.
[BRN ]

103773
[Uses]

Natural insecticide.
[CAS DataBase Reference]

288-14-2(CAS DataBase Reference)
[NIST Chemistry Reference]

Isoxazole(288-14-2)
[EPA Substance Registry System]

288-14-2(EPA Substance)
Safety DataBack Directory
[Hazard Codes ]

F,Xi
[Risk Statements ]

R11:Highly Flammable.
[Safety Statements ]

S16:Keep away from sources of ignition-No smoking .
S33:Take precautionary measures against static discharges .
S29:Do not empty into drains .
S7/9:Keep container tightly closed and in a well-ventilated place .
[RIDADR ]

UN 1993 3/PG 2
[WGK Germany ]

3
[F ]

10
[Hazard Note ]

Highly Flammable
[HazardClass ]

3
[PackingGroup ]

II
[HS Code ]

29349990
Raw materials And Preparation ProductsBack Directory
[Raw materials]

Hydroxylamine hydrochloride-->Malonaldehyde bis(diethyl acetal)
[Preparation Products]

2-Amino-5-chlorobenzophenone-->Clomazone-->2-AMINO-5-CHLOROBENZOPHENONE OXIME-->6-CHLORO-2-(CHLOROMETHYL)-3-OXIDO-4-PHENYL-QUINAZOLINE-->ISAZOPHOS-->Risperidal-->Zonisamide-->5-Chloro-2-(methylamino)benzophenone-->SULFISOXAZOLE ACETYL (200 MG)-->Oxacillin sodium monohydrate
Material Safety Data Sheet(MSDS)Back Directory
[msds information]

Isoxazole(288-14-2).msds
Hazard InformationBack Directory
[Hazard]

Narcotic and psychomimetic effects.
Questions And AnswerBack Directory
[Description]

As an important class of heterocycles, isoxazole is a five membered heterocyclic compound with various pharmacological actions, which is found in some natural products, such as ibotenic acid. It is used in the formation of the basis for a number of drugs, such as the COX-2 inhibitor valdecoxib and anti-inflammatory drugs. Isoxazoles are largely applied in the area of pharmaceuticals and therapeutics, including insecticidal, antibacterial, antibiotic, antitumour, antifungal, antituberculosis, anticancer and ulcerogenic. Besides, it has a great effect on reducing blood glucose, eliminating pain, resisting inflammation, killing harmful bacteria, controlling and reducing the risk of HIV.
The isoxazole ring is an essential pharmacophore in modern drug discovery. Some beta-lactamase-resistant antibiotics contain an isoxazole group, including cloxacillin, dicloxacillin, flucloxacillin, and the isoxazole group is also found in some steroid drug such as danazol.
[References]

https://en.wikipedia.org/wiki/Isoxazole
http://www.ijpcbs.com/files/volume3-2-2013/15.pdf
Spectrum DetailBack Directory
[Spectrum Detail]

Isoxazole(288-14-2)13CNMR
Isoxazole(288-14-2)1HNMR
Isoxazole(288-14-2)IR1
Well-known Reagent Company Product InformationBack Directory
[Acros Organics]

Isoxazole, 99%(288-14-2)
[Alfa Aesar]

Isoxazole, 99%(288-14-2)
[Sigma Aldrich]

288-14-2(sigmaaldrich)
[TCI AMERICA]

Isoxazole,>95.0%(GC)(288-14-2)
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