| Identification | Back Directory | [Name]
2,6-Pyridinedicarbonitrile | [CAS]
2893-33-6 | [Synonyms]
26DCPY
Dipicolinonitrile
2,6-DICYANO PYRIDINE
pyridine-2,6-dinitrile
6-Pyridinedicarbonitrile
6-Isocyanopicolinonitrile
2,6-Pyridinedicarbonitrle
2,6-Pyridinedicarbonitrile
pyridine-2,6-dicarbonitrile
2,6-Pyridinedicarbonitrile 97%
2,6-Pyridinedicarbonitrile(6CI,7CI,8CI,9CI) | [EINECS(EC#)]
220-766-1 | [Molecular Formula]
C7H3N3 | [MDL Number]
MFCD00129021 | [MOL File]
2893-33-6.mol | [Molecular Weight]
129.12 |
| Chemical Properties | Back Directory | [Melting point ]
123-127 °C | [Boiling point ]
290.0±20.0 °C(Predicted) | [density ]
1.25±0.1 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Sealed in dry,Room Temperature | [form ]
solid | [pka]
-5.87±0.10(Predicted) | [color ]
Off-white to light brown | [InChI]
InChI=1S/C7H3N3/c8-4-6-2-1-3-7(5-9)10-6/h1-3H | [InChIKey]
XNPMXMIWHVZGMJ-UHFFFAOYSA-N | [SMILES]
C1(C#N)=NC(C#N)=CC=C1 | [CAS DataBase Reference]
2893-33-6 |
| Hazard Information | Back Directory | [Chemical Properties]
white to off-white powder | [Uses]
2,6-Pyridinedicarbonitrile may be used to synthesize bis-tetrazoles and pyridine-based tridentate ligand 2,6-bis(α-aminoisopropyl)pyridine. | [General Description]
2,6-Pyridinedicarbonitrile is a heterocyclic dinitrile. Its biotransformation by Rhodococcus erythropolis A4 to 6-cyanopyridine-2-carboxamide has been reported. | [Synthesis]
The general procedure for the synthesis of 2,6-pyridinedicarbonitrile from pyridine-2,6-dicarboxylic acid was carried out as follows: liquid ammonia (0.5 ml) and acetonitrile (50 ml) were mixed in a cold bath at -40 °C, followed by the addition of pyridine-2,6-dicarboxylic acid (1.67 g). After raising the temperature of the mixture to 0°C, phosphorus pentachloride (4 g) was added in batches. The reaction mixture was stirred at room temperature for 2 hours to ensure complete reaction. After completion of the reaction, the solvent was removed by concentration under reduced pressure. The residue was dissolved with dichloromethane and subsequently washed with saturated sodium bicarbonate solution to neutrality. The organic layer was dried with anhydrous magnesium sulfate and concentrated again. The resulting solid was recrystallized by isopropanol to give white crystals of 2,6-pyridinedicarbonitrile (1.13 g) in 88% yield. | [References]
[1] Patent: CN105503716, 2016, A. Location in patent: Paragraph 0016
[2] Journal of Organic Chemistry, 2015, vol. 80, # 5, p. 2676 - 2699
[3] Chemical Communications, 2017, vol. 53, # 42, p. 5718 - 5720 |
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