| Identification | Back Directory | [Name]
Methanone, 4-morpholinyl[4-(1H-pyrrolo[2,3-b]pyridin-2-yl)phenyl]- | [CAS]
2913223-17-1 | [Synonyms]
KWCN-41
Methanone, 4-morpholinyl[4-(1H-pyrrolo[2,3-b]pyridin-2-yl)phenyl]- | [Molecular Formula]
C18H17N3O2 | [MOL File]
2913223-17-1.mol | [Molecular Weight]
307.35 |
| Chemical Properties | Back Directory | [density ]
1.299±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted) | [form ]
Solid | [pka]
13.30±0.40(Predicted) | [color ]
Off-white to light yellow |
| Hazard Information | Back Directory | [Uses]
KWCN-41 is a selective and efficient inhibitor of RIPK1 kinase with an IC50 value of 88 nM. KWCN-41 specifically inhibits cell necrosis but does not inhibit apoptosis. KWCN-41 also has anti-inflammatory effects[1]. | [in vivo]
KWCN-41 (10, 25, 40 mg/kg; i.p.; 72 h) dose-dependently inhibits TNF-α-induced death and improves survival in mice[1]. | Animal Model: | Inflammatory mouse model[1] | | Dosage: | 10, 25, 40 mg/kg | | Administration: | i.p.; dissolved in saline containing 10% DMSO and 20% Tween80; 72 h | | Result: | At 25, 40 mg/kg completely inhibited TNF-α induced death in mice, achieving 100% survival compared to 75% survival at 10 mg/kg. |
| [IC 50]
RIPK1: 88 nM (IC50) | [References]
[1] Cui N, et al. Discovery of Sibiriline derivatives as novel receptor-interacting protein kinase 1 inhibitors. Eur J Med Chem. 2023 Mar 15;250:115190. DOI:10.1016/j.ejmech.2023.115190 |
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