| Identification | More | [Name]
Methylprednisolone hemisuccinate | [CAS]
2921-57-5 | [Synonyms]
11beta,17,21-trihydroxy-6alpha-methylpregna-1,4-diene-3,20-dione 21-(hydrogen succinate)
1,4-PREGNADIEN-6-ALPHA-METHYL-11-BETA, 17,21-TRIOL-3,20-DIONE 21-HEMISUCCINATE
6 ALPHA-METHYLPREDNISOLONE HEMISUCCINATE
METHYLPREDINISOLONE HEMISUCCINATE
METHYLPREDNISOLONE HEMISUCCINATE
(6-alpha,11-beta)-yl
4-diene-3,20-dione,11-beta,17,21-trihydroxy-6-alpha-methyl-pregna-21-(hy
4-diene-3,20-dione,11-beta,17,21-trihydroxy-6-alpha-methyl-pregna-21-suc
6-methylprednisolonehemisuccinate
drogensuccinate)
methylprednisolonesuccinate
pregna-1,4-diene-3,20-dione,21-(3-carboxy-1-oxopropoxy)-11,17-dihydroxy-6-meth
Methylprednisolone Hemisuccinate BP/USP/EP
MEGHYLPREDNISOLONE HEMISUCCINATE
METHYLPREDNISOLONEHEMISUCCINATE,USP
METHYLPREDNISOLONE HEMISNCCINATE
6A-METHYLPREDNISOLONEHEMISUCCINATE
Methylprednisolone, Powder
11β,17α-Dihydroxy-3,20-dioxo-6α-methylpregna-1,4-diene-21-ol 21-(4-hydroxy-4-oxobutyrate)
21-(3-Carboxy-1-oxopropoxy)-11β,17-dihydroxy-6α-methyl-1,4-pregnadiene-3,20-dione | [EINECS(EC#)]
220-863-9 | [Molecular Formula]
C26H34O8 | [MDL Number]
MFCD00271782 | [Molecular Weight]
474.54 | [MOL File]
2921-57-5.mol |
| Questions And Answer | Back Directory | [Description]
Methylprednisolone hemisuccinate is a glucocorticoid used to treat severe allergic reactions, asthma, autoimmune diseases, blood disorders, gastrointestinal disorders, and endocrine disorders, among others. | [Synthesis]
Add 6L of dimethyl sulfoxide and 1kg of succinic anhydride in the reaction kettle, stir and dissolve at 25°C, add 0.8L of triethylamine, and stir for 10 minutes; add 1kg of methylprednisolone again, react at 30°C for 3 hours, add 10% hydrochloric acid water Terminate the reaction, separate 40 L of water, and stir for 30 minutes; filter and wash with water to obtain the crude product; the crude product is dissolved in 30 times of methanol temperature, and activated carbon is decolorized to obtain methylprednisolone succinate; the yield is 119%, and the content is 99.3%. |
| Chemical Properties | Back Directory | [Appearance]
White or almost white, hygroscopic powder. | [Melting point ]
>230°C (dec.) | [Boiling point ]
689.6±55.0 °C(Predicted) | [density ]
1.33±0.1 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
Practically insoluble in water, slightly soluble in acetone and in anhydrous ethanol. It dissolves in dilute solutions of alkali hydroxides. | [form ]
neat | [pka]
4.29±0.17(Predicted) | [color ]
White to Off-White | [LogP]
2.69 | [CAS DataBase Reference]
2921-57-5(CAS DataBase Reference) |
| Hazard Information | Back Directory | [Chemical Properties]
White or almost white, hygroscopic powder. | [Uses]
6α-Methylprednisolone 21-Hemisuccinate is a derivative of methylprednisolone (M325934), a glucocorticoid and a anti-inflammatory drug used to treat central nervous system disorders such as multiple sclerosis. 6α-Methylprednisolone 21-Hemisuccinate was examined for potential therapeutic efficacy in a model of neuroinflammation in rats with acute autoimmune encephalomyelitis. | [Uses]
Glucocorticoid. | [Definition]
ChEBI: Methylprednisolone succinate is a corticosteroid hormone and a hemisuccinate. | [Brand name]
A-Methapred (Abbott);
A-Methapred (Hospira); Solu-Medrol (Pharmacia & Upjohn). |
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