| Identification | Back Directory | [Name]
(±)-2-[3-[(tert-butyl)amino]-2-hydroxypropoxy]benzonitrile monohydrochloride | [CAS]
29876-08-2 | [Synonyms]
Betriol
Ko 1366
Koe 1366
Stresson
Ko 1366 hydrochloride
RJPWESHPIMRNNM-UHFFFAOYSA-N
1-tert-Butylamino-3-(2-cyanophenoxy)-2-propanol hydrochloride
1-(2-Cyanophenoxy)-2-hydroxy-3-tert-butylaminopropane hydrochloride
dl-o-[2-Hydroxy-3-(tert-butylamino)propoxy]benzonitrile hydrochloride
(±)-2-[3-[(tert-butyl)amino]-2-hydroxypropoxy]benzonitrile monohydrochloride
Benzonitrile, 2-[3-[(1,1-dimethylethyl)amino]-2-hydroxypropoxy]-, monohydrochloride
Benzonitrile, 2-[3-[(1,1-dimethylethyl)amino]-2-hydroxypropoxy]-, monohydrochloride, (+-)- | [EINECS(EC#)]
249-920-6 | [Molecular Formula]
C14H20N2O2.ClH | [MOL File]
29876-08-2.mol |
| Hazard Information | Back Directory | [Uses]
Bunitrolol hydrochloride is an orally active β-adrenergic blocker that has a high affinity for β-adrenergic receptors. Bunitrolol hydrochloride exerts significant β-receptor antagonist activity and has weak α1-blocking activity. Bunitrolol hydrochloride is mainly used in the study of cardiovascular diseases such as hypertension and angina pectoris, and is also used in placental transport research[1][2][3]. | [Definition]
ChEBI: Bunitrolol hydrochloride is an aromatic ether. | [IC 50]
β-adrenoceptor | [References]
[1] Tsuchihashi H, et al. Effects of bunitrolol on adrenergic and serotonergic receptors. Jpn J Pharmacol. 1987 Nov;45(3):349-56. DOI:10.1254/jjp.45.349
[2] Hasegawa Y, et al. Chronic effects of bunitrolol and pindolol on blood pressure, heart rate, vascular lesions, and plasma renin activity in hypertensive rats. Jpn J Pharmacol. 1982 Aug;32(4):742-5. DOI:10.1254/jjp.32.742
[3] Van Petten G R, et al. Chronic preparation of the pregnant ewe and fetus for pharmacological research: the placental transfer and fetal effects of bunitrolol. Journal of Pharmacological Methods, 1978, 1(1): 45-60. |
|
|