| Identification | More | [Name]
Estazolam | [CAS]
29975-16-4 | [Synonyms]
8-CHLORO-6-PHENYL-4H-[1,2,4]-TRIAZOLO[4,3-A][1,4]BENZODIAZEPINE
ESTAZOLAM
2,4)triazolo(4,3-a)(1,4)-benzodiazepine,8-chloro-6-phenyl-4h-(
3-a)(1,4)benzodiazepine,8-chloro-6-phenyl-4h-s-triazolo(
4H-[1,2,4]Triazolo[4,3-a][1,4]benzodiazepine, 8-chloro-6-phenyl-
4H-s-Triazolo(4,3-a)(1,4)benzodiazepine, 8-chloro-6-phenyl-
8-Chloro-6-phenyl-4H-s-triazolo(4,3-a)(1,4)benzodiazepine
abbott47631
Abbott-47631
Alprazolam M (hydroxy-)-CH2O
Cannoc
D 40TA
d-40ta
Esilgan
estazolam100ugpermlinmethanol
Eurodin
Eurodine
Julodin
Nemurel
Nuctalon | [EINECS(EC#)]
249-982-4 | [Molecular Formula]
C16H11ClN4 | [MDL Number]
MFCD00867537 | [Molecular Weight]
294.74 | [MOL File]
29975-16-4.mol |
| Questions And Answer | Back Directory | [Description]
Estazolam, sold under the brand name Prosom among others, is a tranquilizer medication of the triazolobenzodiazepine (TBZD) class, which are benzodiazepines (BZDs) fused with a triazole ring . It possesses anxiolytic, anticonvulsant, hypnotic, sedative and skeletal muscle relaxant properties. | [Pharmacology]
Estazolam is classed as a "triazolo" benzodiazepine drug.Estazolam exerts its therapeutic effects via its benzodiazepines receptor agonist properties.Estazolam at high doses decreases histamine turnover via its action at the benzodiazepine-GABA receptor complex in mouse brains. | [Adverse reactions]
Common adverse reactions such as drowsiness, drowsiness, dizziness, fatigue, unsteady gait, etc., increasing the dose may occasionally cause adverse reactions such as headache, ataxia, motor dysfunction, slurred speech, respiratory depression, tremor, etc. Long-term use can lead to memory loss Adverse reactions such as decline, weight gain, cognitive impairment, loss of libido, etc. In addition, long-term use of estazolam can cause down-regulation of benzodiazepine receptors in the central nervous system, which can lead to tolerance and dependence, and sudden withdrawal can cause Headache, insomnia, depression, nervousness, restlessness, irritability, anxiety, tremor, tachycardia and other withdrawal symptoms, namely drug addiction, are the most serious adverse reactions of long-term use of estazolam. |
| Chemical Properties | Back Directory | [Melting point ]
228-229° | [Boiling point ]
448.04°C (rough estimate) | [density ]
1.2294 (rough estimate) | [refractive index ]
1.6110 (estimate) | [Fp ]
11 °C | [storage temp. ]
2-8°C | [solubility ]
DMF: 30 mg/ml; DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml; DMSO: 20 mg/ml; Ethanol: 10 mg/ml | [form ]
A crystalline solid | [pka]
pKa 2.84(H2O) (Uncertain) | [CAS DataBase Reference]
29975-16-4(CAS DataBase Reference) | [IARC]
3 (Vol. 66) 1996 | [NIST Chemistry Reference]
Estazolam(29975-16-4) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi,T,F | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin .
R39/23/24/25:Toxic: danger of very serious irreversible effects through inhalation, in contact with skin and if swallowed .
R23/24/25:Toxic by inhalation, in contact with skin and if swallowed .
R11:Highly Flammable. | [Safety Statements ]
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S36/37:Wear suitable protective clothing and gloves .
S16:Keep away from sources of ignition-No smoking .
S7:Keep container tightly closed . | [RIDADR ]
3249 | [WGK Germany ]
3
| [RTECS ]
XZ5473500
| [HazardClass ]
6.1(b) | [PackingGroup ]
III | [HS Code ]
2933910000 | [Toxicity]
LD50 orally in male mice, rats and rabbits: 740, 3200, 300 mg/kg (Yokotani) |
| Hazard Information | Back Directory | [Originator]
Eurodin,Takeda,Japan,1975 | [Uses]
A benzodiazepine derivative possessing anxiolytic, anticonvulsant, and muscle relaxant properties. It is commonly prescribed to treat short-term insomnia.
Controlled Substance. | [Definition]
ChEBI: A triazolo[4,3-a][1,4]benzodiazepine having a phenyl group at position 6 and a chloro substituent at position 8. A short-acting benzodiazepine with general properties similar to diazepam, it is given by mouth as a hypnotic in the short-term ma
agement of insomnia. | [Manufacturing Process]
A mixture of 5.74 grams (0.020 mol) of 7-chloro-1,3-dihydro-5-phenyl-2H-
1,4-benzodiazepine-2-thione, 3.6 grams (0.060 mol) of formic acid hydrazide
and 200 ml of 1-butanol was refluxed for 3.75 hours with a slow stream of
nitrogen bubbling through the mixture. The mixture was concentrated, the
residue was suspended in water and the suspension was filtered. The filter
cake consisted principally of unchanged starting material. The filtrate was
concentrated, ethyl acetate and Skellysolve B hexanes being added during the
concentration, giving crude product (2.54 grams), MP 220.5° to 225°C.
Recrystallization of this material from ethyl acetate-Skellysolve B hexanes
gave 8-chloro-6-phenyl-4H-s-triazolo[4,3-a] [1,4]benzodiazepine, MP 228° to
229°C. | [Brand name]
Prosom (Abbott). | [Therapeutic Function]
Hypnotic, Sedative |
|