| Identification | Back Directory | [Name]
Ro 01-6128 | [CAS]
302841-86-7 | [Synonyms]
Ro 01-6128
ILSZPWZFQHSKLW-UHFFFAOYSA-N
ethyl N-[2,2-di(phenyl)acetyl]carbamate
(Diphenylacetyl)-carbamic acid ethy ester | [Molecular Formula]
C17H17NO3 | [MDL Number]
MFCD20270619 | [MOL File]
302841-86-7.mol | [Molecular Weight]
283.32 |
| Chemical Properties | Back Directory | [density ]
1.156±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble to 100 mM in DMSO and to 100 mM in ethanol | [form ]
Powder | [pka]
7.97±0.46(Predicted) | [color ]
White to light brown |
| Hazard Information | Back Directory | [Description]
Glutamate, the major excitatory neurotransmitter in the CNS, activates eight known subtypes of metabotropic glutamate receptors (mGluRs). Highly selective modulators designed to act at allosteric sites on certain mGluR subtypes are being developed to preferentially regulate subtype-specific, glutamate-induced receptor activation. Ro 01-6128 is a positive allosteric modulator of mGluR1 that can potentiate glutamate-induced calcium release at rat mGluR1a with an EC50 value of 104 nM. Ro 01-6128 activates ERK1/2 phosphorylation in the absence of exogenously added glutamate with an EC50 value of 248 nM and potentiates glutamate-induced cAMP production with an EC50 value of 21.5 μM. | [Uses]
Ro 01-6128 is an allosteric mGluR-1 activator. | [IC 50]
mGluR 1 | [References]
[1] KAMONDANAI HEMSTAPAT. A novel class of positive allosteric modulators of metabotropic glutamate receptor subtype 1 interact with a site distinct from that of negative allosteric modulators.[J]. Molecular Pharmacology, 2006, 70 2: 616-626. DOI: 10.1124/mol.105.021857 |
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