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302841-89-0

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302841-89-0 Structure

302841-89-0 Structure
IdentificationBack Directory
[Name]

Ro 67-4853
[CAS]

302841-89-0
[Synonyms]

Ro 67-4853
Butyl 9H-xanthene-9-carbonylcarbamate
(9H-Xanthen-9-ylcarbonyl)carbaMic Acid Butyl Ester
N-(9H-Xanthen-9-ylcarbonyl)carbaMic Acid Butyl Ester
Carbamic acid, N-(9H-xanthen-9-ylcarbonyl)-, butyl ester
[Molecular Formula]

C19H19NO4
[MDL Number]

MFCD20270618
[MOL File]

302841-89-0.mol
[Molecular Weight]

325.36
Chemical PropertiesBack Directory
[Melting point ]

190-194°C
[storage temp. ]

Refrigerator
[solubility ]

Chloroform, Methanol
[form ]

Solid
[color ]

White
Safety DataBack Directory
[Symbol(GHS) ]

Exclamation Mark (GHS07)Health Hazard (GHS08)Environment (GHS09)
GHS07,GHS08,GHS09
[Signal word ]

Danger
[Hazard statements ]

H302-H361-H372-H410
[Precautionary statements ]

P201-P264-P280-P301+P330+P331-P312
Hazard InformationBack Directory
[Uses]

Ro 67-4853 is a positive allosteric modulator of metabotropic glutamate 1 receptor (1,2). Ro 67-4853 exhibits activity at all group I receptors such as human and rat mGlu1/mGlu5. It also enhance glutamate-induced calcium signaling through both the human and mouse mGlu1a receptors.
[IC 50]

Rat mGluR1a: 7.16 (pEC50)
[storage]

Store at RT
Spectrum DetailBack Directory
[Spectrum Detail]

Ro 67-4853(302841-89-0)1HNMR
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