Back to ChemicalBook Home--->CAS DataBase List--->305-03-3

305-03-3

305-03-3 Structure

305-03-3 Structure
IdentificationMore
[Name]

Chloroambucil
[CAS]

305-03-3
[Synonyms]

4-[BIS(2-CHLOROETHYL)AMINO]BENZENEBUTANOIC ACID
4-[BIS(2-CHLOROETHYL)AMINO]BENZENEBUTYRIC ACID
4-[bis(2-chloroethyl)aminophenyl]butyric acid
4-[P-(BIS[2-CHLOROETHYL]AMINO)-PHENYL]BUTYRIC ACID
4-(p-(n,n-di-2-chloroethyl)aminophenyl)butyric acid
CHLORAMBUCIL
chloroambucil
3-[bis(2-chloroethyl)amino]benzenebutanoicacid
4-(4-[Bis(2-chloroethyl)amino]phenyl)butanoic acid
4-(bis(2-chloroethyl)amino)-benzenebutanoicaci
4-(bis(2-chloroethyl)amino)benzene-butanoicaci
4-(p-bis(2-chloroethyl)aminophenyl)-butyricaci
4-(p-Bis(beta-chloroethyl)aminophenyl)butyric acid
4(p-bis(beta-chloroethyl)aminophenyl)butyricacid
4-[Bis(2-chioroethyl)amino]benzenebutanoicacid
Ambochlorin
Amboclorin
Benzenebutanoic acid, 4-[bis(2-chloroethyl)amino]-
Butanoic acid, 4-(bis(2-chloroethyl)amino)benzene-
butanoicacid,4-[3-[bis(2-chloroethyl)amino]phenyl]-
[EINECS(EC#)]

206-162-0
[Molecular Formula]

C14H19Cl2NO2
[MDL Number]

MFCD00021783
[Molecular Weight]

304.21
[MOL File]

305-03-3.mol
Chemical PropertiesBack Directory
[Appearance]

beige powder
[Appearance]

Chlorambucil is a crystalline solid
[mp ]

65-70 °C
[storage temp. ]

2-8°C
[Stability:]

Stable, but may be light sensitive. Store cold. Incompatible with strong oxidizing agents.
[Water Solubility ]

<0.01 g/100 mL at 22 ºC
[Merck ]

13,2083
[CAS DataBase Reference]

305-03-3(CAS DataBase Reference)
[NIST Chemistry Reference]

Chlorambucil(305-03-3)
[EPA Substance Registry System]

305-03-3(EPA Substance)
Safety DataBack Directory
[Hazard Codes ]

T
[Risk Statements ]

R45:May cause cancer.
R25:Toxic if swallowed.
R36/37/38:Irritating to eyes, respiratory system and skin .
[Safety Statements ]

S53:Avoid exposure-obtain special instruction before use .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
[RIDADR ]

UN 2811 6.1/PG 3
[WGK Germany ]

3
[RTECS ]

ES7525000
[HazardClass ]

6.1(b)
[PackingGroup ]

III
[HS Code ]

29224999
[Safety Profile]

Confirmed carcinogen producing leukemia. Experimental carcinogenic and neoplastigenic data. Poison by ingestion, intravenous, intraperitoneal, and subcutaneous routes. Human systemic effects by ingestion: convulsions, cough, dyspnea, and interstitial fibrosis. Human reproductive effects by ingestion and possibly other routes: changes in spermatogenesis, menstrual cycle changes or disorders, and teratogenic effects of the fetal urogenital system. Experimental teratogenic and reproductive effects. Human mutation data reported. An anti-neoplastic agent. When heated to decomposition it emits very toxic fumes of Cland NOx.
[Hazardous Substances Data]

305-03-3(Hazardous Substances Data)
Raw materials And Preparation ProductsBack Directory
[Raw materials]

Phosphorus oxychloride-->4-Phenylbutyric acid
Hazard InformationBack Directory
[General Description]

White to pale beige crystalline or granular powder with a slight odor. Melting point 65-69°C.
[Reactivity Profile]

CHLORAMBUCIL(305-03-3) is an alkylating agent. Reacts with proteins and a variety of nucleophilic compounds .
[Air & Water Reactions]

Insoluble in water.
[Potential Exposure]

Chlorambucil, an anticancer drug, is a derivative of nitrogen mustard. This drug is primarily used as an antineoplastic agent for treating lymphocytic leukemia; malignant lymphomas; follicular lymphoma; and Hodgkin’s disease. The treatments are not curative but do produce some marked remissions. Chlorambucil has also been tested for treatment of chronic hepatitis, rheumatoid arthritis; and as an insect chemosterilant. All of the chemical used in this country is imported from the United Kingdom. Work exposure in the United States would be limited to workers formulating the tablets, or to those patients receiving the drug.
[Fire Hazard]

Literature sources indicate that this chemical is nonflammable.
[First aid]

Move victim to fresh air. Call 911 or emergency medical service. Give artificial respiration if victim is not breathing. Do not use mouth-to-mouth method if victim ingested or inhaled the substance; give artificial respiration with the aid of a pocket mask equipped with a one-way valve or other proper respiratory medical device. Administer oxygen if breathing is difficult. Remove and isolate contaminated clothing and shoes. In case of contact with substance, immediately flush skin or eyes with running water for at least 20 minutes. For minor skin contact, avoid spreading material on unaffected skin. Keep victim warm and quiet. Effects of exposure (inhalation, ingestion, or skin contact) to substance may be delayed. Ensure that medical personnel are aware of the material(s) involved and take precautions to protect themselves. Medical observation is recommended for 24 to 48 hours after breathing overexposure, as pulmonary edema may be delayed. As first aid for pulmonary edema, a doctor or authorized paramedic may consider administering a drug or other inhalation therapy.
[Shipping]

UN2811 Toxic solids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required.
[Incompatibilities]

Moisture. Chlorambucil is an alkylating agent. Reacts with proteins and a variety of nucleophilic compounds. Compounds of the carboxyl group react with all bases, both inorganic and organic (i.e., amines) releasing substantial heat, water, and a salt that may beharmful. Incompatible with arsenic compounds (releases hydrogen cyanide gas), diazo compounds, dithiocarbamates, isocyanates, mercaptans, nitrides, sulfides (releasing heat, toxic, and possibly flammable gases), thiosulfates, and dithionites (releasing hydrogen sulfate and oxides of sulfur).
[Waste Disposal]

It is inappropriate and possibly dangerous to the environment to dispose of expired or waste drugs and pharmaceuticals by flushing them down the toilet or discarding them to the trash. Household quantities of expired or waste pharmaceuticals may be mixed with wet cat litter or coffee grounds, double-bagged in plastic, discard in trash. Larger quantities shall carefully take into consideration applicable DEA, EPA, and FDA regulations. If possible return the pharmaceutical to the manufacturer for proper disposal being careful to properlylabel and securely package the material. Alternatively, the waste pharmaceutical shall be labeled, securely packaged, and transported by a state licensed medical waste contractor to dispose by burial in a licensed hazardous or toxic waste landfill or incinerator. Permanganate oxidation, high temperature incineration with scrubbing equipment, or microwave plasma treatment.
Material Safety Data Sheet(MSDS)Back Directory
[msds information]

Chloroambucil(305-03-3).msds
Well-known Reagent Company Product InformationBack Directory
[Sigma Aldrich]

305-03-3(sigmaaldrich)
305-03-3 suppliers list
Company Name: Capot Chemical Co.,Ltd.
Tel: +86 (0)571-855 867 18
Fax: +86 (0)571-858 647 95
Website: www.capotchem.com
Company Name: Biochempartner
Tel: 0086-13720134139
Fax:
Website: www.biochempartner.com
Company Name: Shenzhen Nexconn Pharmatechs Ltd
Tel: 15013857715
Fax:
Website: www.chemicalbook.com/ShowSupplierProductsList31188/0.htm
Company Name: Hubei xin bonus chemical co. LTD
Tel: 86-13657291602
Fax: 027-59338440
Website: www.chemicalbook.com/ShowSupplierProductsList1549548/0.htm
Company Name: Chemwill Asia Co.,Ltd.
Tel: 86-21-51086038
Fax: 86-21-51861608
Website: www.chemwill.com
Company Name: ATK CHEMICAL COMPANY LIMITED
Tel: +86 21 5161 9050/ 5187 7795
Fax: +86 21 5161 9052/ 5187 7796
Website: www.atkchemical.com
Company Name: Henan DaKen Chemical CO.,LTD.
Tel: +86-371-55531817
Fax:
Website: www.dakentech.com
Company Name: PI & PI BIOTECH INC.
Tel: 020-81716320
Fax: 020-81716319
Website: www.pipitech.com
Company Name: Mainchem Co., Ltd.
Tel: +86-0592-6210733
Fax: +86-0592-6210733
Website: www.mainchem.com
Company Name: Henan Tianfu Chemical Co.,Ltd.
Tel: 0371-55170693
Fax: 0371-55170693
Website: www.tianfuchem.net
Company Name: Taizhou Corey Biotechnology Co. Ltd.  Gold
Tel:13396860566
Fax:
Website:www.pharm-intermediates.com
Company Name: Suzhou Pharmaceutical Technology co.,ltd  Gold
Tel:400-000-6498
Fax:051282177481
Website:www.fmyykj.com
Company Name: J & K SCIENTIFIC LTD.  
Tel:400-666-7788 +86-10-82848833
Fax:86-10-82849933
Website:www.jkchemical.com
Company Name: Chembest Research Laboratories Limited  
Tel:+86(0)21-20908456
Fax:+86(0)21-58180499
Website:www.biochembest.com
Company Name: TCI (Shanghai) Development Co., Ltd.  
Tel:021-67121386 / 800-988-0390
Fax:021-67121385
Website:www.tcichemicals.com
Company Name: Wuhan Chemwish Technology Co., Ltd  
Tel:86-027-67849912
Fax:86-027-87531808
Website:www.chemwish.com
Company Name: Shanghai Sinch Parmaceuticals Tech. Co. Ltd.  
Tel:+86-21-54098501
Fax:+86-21-54096319
Website:www.sinch.com.cn
Company Name: Shanghai Hanhong Scientific Co.,Ltd.  
Tel:021-54306202,021-54308259
Fax:+86-21-64545202
Website:www.chemto.com
Tags:305-03-3 Related Product Information
1043-21-6 107-92-6 6317-18-6 56-12-2 154-93-8 1821-12-1 55-86-7 622-24-2 15118-60-2 2998-57-4 305-03-3