| Identification | Back Directory | [Name]
5-BROMO-2-(METHYLAMINO)PYRIMIDINE | [CAS]
31402-54-7 | [Synonyms]
5-BROMO-2-(METHYLAMINO)
5-Bromo-2-(methylamino)pyridine
5-BROMO-2-(METHYLAMINO)PYRIMIDINE
2-(Methylamino)-5-bromopyrimidine
5-bromo-N-methylpyrimidin-2-amine
5-Bromo-N-methyl-2-pyrimidinamine
(5-BROMOPYRIMIDIN-2-YL)METHYLAMINE
2-Pyrimidinamine, 5-bromo-N-methyl-
Pyrimidine, 5-bromo-2-(methylamino)-
N-(5-Bromopyrimidin-2-yl)-N-methylamine
(5-BROMOPYRIMIDIN-2-YL)METHYLAMINE, 95+%
REF DUPL: N-(5-Bromopyrimidin-2-yl)-N-methylamine
5-BROMO-2-(METHYLAMINO)PYRIMIDINE ISO 9001：2015 REACH | [Molecular Formula]
C5H6BrN3 | [MDL Number]
MFCD07368227 | [MOL File]
31402-54-7.mol | [Molecular Weight]
188.03 |
| Chemical Properties | Back Directory | [Melting point ]
171-173℃ | [Boiling point ]
283.5±32.0 °C(Predicted) | [density ]
1.686±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C(protect from light) | [pka]
2.07±0.10(Predicted) | [Appearance]
White to off-white Solid |
| Hazard Information | Back Directory | [Synthesis]
1. 5-Bromo-2-chloropyrimidine (3 g, 15.5 mmol), 40% aqueous methylamine (35 ml) and methanol (20 ml) were added to a reaction flask and mixed well with stirring. 2. The reaction mixture was heated to reflux and kept at that temperature for 3 days. 3. After completion of the reaction, the reaction was cooled to room temperature. 4. The solvent was removed by evaporation using a rotary evaporator under reduced pressure. 5. The residue was extracted by partitioning with dichloromethane and 1M sodium hydroxide. 6. The residue was extracted by partitioning with dichloromethane and 1 M sodium hydroxide solution. 6. The organic layer was separated and dried over anhydrous magnesium sulfate. 7. After filtration to remove the desiccant, the solvent was again evaporated under reduced pressure using a rotary evaporator to give the white solid product 5-bromo-2-methylaminopyrimidine (3.0 g, 100% yield). 8. The product was characterized by 1H-NMR (CDCl3): δ 2.98 (3H, d, J=5.12 Hz), 5.16 (1H, brs), 8.29 (2H, s). | [References]
[1] Patent: US2010/130492, 2010, A1. Location in patent: Page/Page column 93
[2] Patent: WO2010/12747, 2010, A1. Location in patent: Page/Page column 16-17
[3] Patent: WO2007/84786, 2007, A1. Location in patent: Page/Page column 90
[4] ACS Medicinal Chemistry Letters, 2011, vol. 2, # 1, p. 34 - 38
[5] Patent: WO2012/109423, 2012, A1. Location in patent: Page/Page column 18 |
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