| Identification | More | [Name]
Dimethyl L-aspartate hydrochloride | [CAS]
32213-95-9 | [Synonyms]
ASPARTIC ACID-1,4-DIMETHYL ESTER HYDROCHLORIDE
ASPARTIC ACID(OME)-OME HCL
DIMETHYL L-ASPARAGINATE HYDROCHLORIDE
DIMETHYL L-ASPARTATE HYDROCHLORIDE
DIMETHYL (S)-AMINOSUCCINATE HYDROCHLORIDE
H-ASP(OME)-OME HCL
H-ASP(OME)-OME HYDROCHLORIDE
H-L-ASP(ME)-OME HCL
L-ASPARAGINIC ACID DIMETHYL ESTER HYDROCHLORIDE
L-ASPARTIC ACID ALPHA,BETA-DIMETHYL ESTER HYDROCHLORIDE
L-ASPARTIC ACID DIMETHYL ESTER HCL
L-ASPARTIC ACID DIMETHYL ESTER HYDROCHLORIDE
L-ASPARTIC ACID, DIMETHYL ESTER, HYDROCHLORIDE SALT
(S)-AMINOSUCCINIC ACID DIMETHYL ESTER HYDROCHLORIDE
L-Asparatic acid dimethyl ester hydrochloride
L-Aspartic Acid Diemthyl Ester HCl
L-ASPARTIC ACID-1,4-DIMETHYL ESTER HYDROCHLORIDE
H-Asp(OMe)-OMe
L-ASPARTIC ACID A,B-DIMETHYLESTER HYDROCHLORIDE
L-Aspartic acid dimethyl·hydrochloric acid | [EINECS(EC#)]
250-957-5 | [Molecular Formula]
C6H12ClNO4 | [MDL Number]
MFCD00038878 | [Molecular Weight]
197.62 | [MOL File]
32213-95-9.mol |
| Chemical Properties | Back Directory | [Appearance]
white to off-white crystalline powder | [Melting point ]
115-117 °C(lit.) | [alpha ]
15 º (c=1, MeOH) | [refractive index ]
12 ° (C=1.4, H2O) | [storage temp. ]
−20°C
| [solubility ]
DMSO (Slightly), Methanol (Slightly), Water (Slightly) | [form ]
Powder | [color ]
White to Off-white | [Water Solubility ]
Soluble in water (almost transparency) and methanol. | [Major Application]
peptide synthesis | [InChI]
InChI=1/C6H11NO4.ClH/c1-10-5(8)3-4(7)6(9)11-2;/h4H,3,7H2,1-2H3;1H/t4-;/s3 | [InChIKey]
PNLXWGDXZOYUKB-WCCKRBBISA-N | [SMILES]
[C@@H](N)(C(=O)OC)CC(=O)OC.Cl |&1:0,r| | [CAS DataBase Reference]
32213-95-9(CAS DataBase Reference) |
| Hazard Information | Back Directory | [Chemical Properties]
white to off-white crystalline powder | [Uses]
Dimethyl L-Aspartate Hydrochloride was used in the synthesis of enzyme and pH dual responsive L-amino acid based biodegradable polymer nanocarrier that can be used for multidrug delivery to cancer cells. | [reaction suitability]
reaction type: solution phase peptide synthesis | [Synthesis]
Example 1; This example demonstrates the synthesis of dimethyl (S)-2-aminosuccinate hydrochloride from L-aspartic acid. The steps were as follows: a solution of L-aspartic acid (13.5 g, 100 mmol) dissolved in 100 ml of methanol was slowly added dropwise to pure thionyl chloride, and the reaction mixture was stirred continuously for 48 hours at room temperature. After completion of the reaction, the reaction mixture was concentrated in vacuum using a rotary evaporator. Subsequently, it was extracted and washed by adding methanol (3 x 30 ml) and dichloromethane (3 x 30 ml) to finally obtain L-aspartic acid dimethyl ester hydrochloride (19.5 g, quantitative yield) in white powder form. | [References]
[1] Organic and Biomolecular Chemistry, 2009, vol. 7, # 20, p. 4309 - 4316
[2] Patent: US2007/142467, 2007, A1. Location in patent: Page/Page column 5
[3] Chemical Communications, 2011, vol. 47, # 23, p. 6569 - 6571
[4] Journal of Medicinal Chemistry, 2012, vol. 55, # 23, p. 10460 - 10474
[5] Organic and Biomolecular Chemistry, 2015, vol. 13, # 15, p. 4514 - 4523 |
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J & K SCIENTIFIC LTD.
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18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
Energy Chemical
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400-0056266 18918157536; |
| Website: |
http://www.energy-chemical.com |
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