| Identification | More | [Name]
3,5-Di(trifluoromethyl)aniline | [CAS]
328-74-5 | [Synonyms]
3,5-BIS(TRIFLUOROMETHYL)ANILINE
3,5-DI(TRIFLUOROMETHYL)ANILINE
5-AMINO-ALPHA,ALPHA,ALPHA,ALPHA',ALPHA',ALPHA'-HEXAFLUORO-M-XYLENE
A,A,A,A',A',A'-HEXAFLUORO-3,5-XYLIDINE
AKOS BBS-00003710
ALPHA,ALPHA,ALPHA,ALPHA',ALPHA',ALPHA'-HEXAFLUORO-3,5-XYLIDINE
MBT-NH2
TIMTEC-BB SBB000690
,,,’,’,’-Hexafluoro-3,5-xylidine
,5-Bis-trifluoromethyl-phenylamine
,5-Xylidine, a,a,a,a',a',a'-hexafluoro-
,a,a,a',a',a'-Hexafluoro-3,5-xylidine
3,5-bis(trifluoromethyl)-anilin
3,5-bis(trifluoromethyl)-benzenamin
3,5-Bis(trifluoromethyl)benzenamine
3,5-Xylidine, alpha,alpha,alpha,alpha',alpha',alpha'-hexafluoro-
3,5-Xylidine, alpha,alpha,alpha,alpha,alpha,alpha-hexafluro-
alpha,alpha,alpha,alpha’,alpha’,alpha’-hexafluoro-5-xylidine
Aniline, 3,5-bis(trifluoromethyl)-
3,5-BIS(TRIFLUOROMETHYL)AMILINE | [EINECS(EC#)]
206-335-0 | [Molecular Formula]
C8H5F6N | [MDL Number]
MFCD00000394 | [Molecular Weight]
229.12 | [MOL File]
328-74-5.mol |
| Chemical Properties | Back Directory | [Appearance]
clear light yellow to yellow-brown liquid | [Melting point ]
168.2-169.2 °C | [Boiling point ]
85 °C15 mm Hg(lit.)
| [density ]
1.467 g/mL at 25 °C(lit.)
| [refractive index ]
n20/D 1.434(lit.)
| [Fp ]
182 °F
| [storage temp. ]
Keep in dark place,Sealed in dry,Room Temperature | [form ]
Liquid | [pka]
2.15±0.10(Predicted) | [color ]
Clear light yellow to yellow-brown | [Specific Gravity]
1.473 | [Water Solubility ]
Not miscible in water. | [BRN ]
654318 | [InChI]
1S/C8H5F6N/c9-7(10,11)4-1-5(8(12,13)14)3-6(15)2-4/h1-3H,15H2 | [InChIKey]
CDIDGWDGQGVCIB-UHFFFAOYSA-N | [SMILES]
Nc1cc(cc(c1)C(F)(F)F)C(F)(F)F | [CAS DataBase Reference]
328-74-5(CAS DataBase Reference) | [NIST Chemistry Reference]
Benzenamine, 3,5-bis(trifluoromethyl)-(328-74-5) | [EPA Substance Registry System]
328-74-5(EPA Substance) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi,Xn | [Risk Statements ]
R33:Danger of cumulative effects.
R36/37/38:Irritating to eyes, respiratory system and skin .
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S36:Wear suitable protective clothing . | [RIDADR ]
2810 | [WGK Germany ]
3
| [RTECS ]
ZE9800000
| [Hazard Note ]
Irritant | [TSCA ]
Yes | [HazardClass ]
6.1 | [PackingGroup ]
III | [HS Code ]
29214910 | [Storage Class]
10 - Combustible liquids | [Hazard Classifications]
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| Raw materials And Preparation Products | Back Directory | [Raw materials]
Toluene-->Nitric acid | [Preparation Products]
5,7-BIS(TRIFLUOROMETHYL)-4-CHLOROQUINOLINE-->5,7-BIS(TRIFLUOROMETHYL)-4-HYDROXYQUINOLINE-->IMD-0354-->5,7-BIS(TRIFLUOROMETHYL)-4-HYDROXYQUINOLINE-3-CARBOXYLIC ACID-->4-HYDROXY-5,7-BIS-TRIFLUOROMETHYL-QUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER-->3,5-Bis(trifluoromethyl)phenol-->3,5-bis(trifluoromethyl)benzenediazonium-->3,5-BIS(TRIFLUOROMETHYL)-N-(BROMOACETYL)ANILINE-->tert-butyl 3,5-bis(trifluoromethyl)phenylcarbamate-->2-(2-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]HYDRAZONO)MALONONITRILE-->1-[3,5-Bis(trifluoromethyl)phenyl]-3-[4-(trifluoromethyl)phenyl]urea, 97%-->N1-methyl-3,5-di(trifluoromethyl)aniline |
| Hazard Information | Back Directory | [Chemical Properties]
clear light yellow to yellow-brown liquid | [Uses]
3,5-Bis(trifluoromethyl)aniline was used in the synthesis of N-[2-hydroxy-1-naphthylidene]-3, 5-bis(trifluoromethyl)aniline, Schiff?s base and 5,7-bis(trifluoromethyl)aniline. It was also used in the synthesis of N-1-phenylethyl-3,5-bis(trifluoromethyl)aniline via titanium-catalyzed hydroamination reaction and N,N?-bis[3,5-bis(tri-fluoromethyl)phenyl]thiourea, organocatalyst. | [Synthesis]
The synthesis of 3,5-Bis(trifluoromethyl)aniline is as follows is as follows：Put 259g (1mol) 3,5-Bis(trifluoromethyl)nitrobenzeneand 500g ethyl acetate into a 1L autoclave, add 5g palladium-carbon as a catalyst, raise the temperature to 60℃, then pass the hydrogen pressure to 2MPa, keep the temperature and react for 20 hours, then cooling, filtration, concentration, and distillation to obtain 3,5-Bis(trifluoromethyl)aniline with a purity of 98.5% and a yield of 87%.
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