| Identification | More | [Name]
3-Methoxy-5-nitrobenzotrifluoride | [CAS]
328-79-0 | [Synonyms]
3-METHOXY-5-NITROBENZOTRIFLUORIDE
TIMTEC-BB SBB010016
1-Methoxy-3-nitro-5-(trifluoromethyl)benzene
3-Methoxy-5-nitrobenzotrifluoride 99%
3-Methoxy-5-nitrobenzotrifluoride99%
5-methoxy-3-nitrobenzotrifluoride | [Molecular Formula]
C8H6F3NO3 | [MDL Number]
MFCD00010446 | [Molecular Weight]
221.13 | [MOL File]
328-79-0.mol |
| Safety Data | Back Directory | [Hazard Codes ]
C,Xi | [Risk Statements ]
R34:Causes burns.
R36/38:Irritating to eyes and skin .
R21/22:Harmful in contact with skin and if swallowed . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S27:Take off immediately all contaminated clothing .
S28:After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer) .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) . | [RIDADR ]
UN 1759 8/PG 2
| [WGK Germany ]
3
| [Hazard Note ]
Irritant | [HazardClass ]
8 | [PackingGroup ]
III | [HS Code ]
2909309090 |
| Hazard Information | Back Directory | [Uses]
3-Methoxy-5-nitrobenzotrifluoride may be used in chemical synthesis. | [Synthesis]
To a solution of 3,5-dinitrobenzotrifluoride (10 g, 42.4 mmol) in anhydrous methanol (100 mL) was slowly added a solution of sodium methanolate (3.43 g, 63.5 mmol) in anhydrous methanol (20 mL). The reaction mixture was heated to reflux for 1 hour and subsequently concentrated by rotary evaporation to remove the methanol solvent. The concentrated residue was diluted with ethyl acetate (80 mL) and water (30 mL) to separate the organic phase. The organic phase was dried over anhydrous sodium sulfate (Na2SO4), filtered and concentrated to give 3-nitro-5-(trifluoromethyl)anisole (8.5 g) as a red solid. The product was analyzed by LC-MS (ESI): no [M + H]+ peak was observed; retention time was 1.85 min. | [References]
[1] Journal of the Chemical Society, 1951, p. 2013,2016
[2] Journal of the American Chemical Society, 1955, vol. 77, p. 2284,2285
[3] Patent: WO2013/13503, 2013, A1. Location in patent: Page/Page column 43 |
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