Back to ChemicalBook Home--->CAS DataBase List--->88-72-2

88-72-2

88-72-2 Structure

88-72-2 Structure
IdentificationMore
[Name]

2-Nitrotoluene
[CAS]

88-72-2
[Synonyms]

1-METHYL-2-NITROBENZENE
2-methyl-1-nitrobenzene
2-METHYLNITROBENZENE
2-NITROTOLUENE
2-Nitrotoluol
ALPHA-METHYLNITROBENZENE
o-nitrophenylmethane
O-NITROTOLUENE
1-methyl-2-nitro-benzen
Benzene,1-methyl-2-nitro-
nsc9577
o-Methylnitrobenzene
o-nitro-toluen
o-nitrotoluol
ONT
ortho-nitrotoluol
Toluene, o-nitro-
Ortho Nitrotoluene
2-NITROTOLUENE, 99+%
2-NITROTOLUENE,1X1ML, ACN 1000UG/ML
[EINECS(EC#)]

201-853-3
[Molecular Formula]

C7H7NO2
[MDL Number]

MFCD00007157
[Molecular Weight]

137.14
[MOL File]

88-72-2.mol
Chemical PropertiesBack Directory
[Description]

o-Nitrotoluene is a yellow-coloured liquid. It is used for the synthesis of a variety of industrial products. These include to synthesise agricultural and rubber chemicals, azo and sulphur dyes, and dyes for cotton, wool, silk, leather, and paper. O-nitrotoluene decomposes on contact with strong oxidants, reducing agents, acids, or bases producing toxic fumes, nitrogen oxides, and carbon monoxide.
[Appearance]

light yellow to darker yellow-green liquid
[Appearance]

Nitrotoluene is formed in 3 isomeric forms. The o-and m-forms are yellow liquids or solids. The p-form is a pale yellow crystalline solid. All have weak aromatic odors. The Odor Thresholds are: 0.05 mg/L (o-isomer); 1.74 ppm (m-isomer).
[mp ]

-9 °C
[bp ]

225 °C(lit.)
[density ]

1.163 g/mL at 25 °C(lit.)
[refractive index ]

n20/D 1.546(lit.)
[Fp ]

223 °F
[storage temp. ]

2-8°C
[Stability:]

Stable. Combustible. Incompatible with oxidizing agents, strong bases, sulfuric acid, reducing agents, hydrogen, sodium.
[Water Solubility ]

0.44 g/L (20 ºC)
[Merck ]

14,6650
[BRN ]

1907580
[CAS DataBase Reference]

88-72-2(CAS DataBase Reference)
[NIST Chemistry Reference]

Benzene, 1-methyl-2-nitro-(88-72-2)
[EPA Substance Registry System]

88-72-2(EPA Substance)
Safety DataBack Directory
[Hazard Codes ]

T,N,F
[Risk Statements ]

R45:May cause cancer.
R22:Harmful if swallowed.
R51/53:Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment .
R62:Possible risk of impaired fertility.
R36/37/38:Irritating to eyes, respiratory system and skin .
R23/24/25:Toxic by inhalation, in contact with skin and if swallowed .
R11:Highly Flammable.
[Safety Statements ]

S53:Avoid exposure-obtain special instruction before use .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S61:Avoid release to the environment. Refer to special instructions safety data sheet .
S27:Take off immediately all contaminated clothing .
S16:Keep away from sources of ignition-No smoking .
[RIDADR ]

UN 1664 6.1/PG 2
[WGK Germany ]

3
[RTECS ]

XT3150000
[HazardClass ]

6.1
[PackingGroup ]

II
[HS Code ]

29042000
[Safety Profile]

Confirmed carcinogen. A poison. Moderately toxic by ingestion. Mucous membrane effects by inhalation. Mutation data reported. Combustible when exposed to heat or open flame. To fight fire, use water spray, fog, foam, CO2. Potentially explosive reaction with alkali (e.g., sodmm hydroxide). When heated to decomposition it emits toxic fumes of NOx. See also other methylnitrobenzene entries and NITRO COMPOUNDS OF AROMATIC HYDROCARBONS.
[Hazardous Substances Data]

88-72-2(Hazardous Substances Data)
Raw materials And Preparation ProductsBack Directory
【Raw materials】

Sodium hydroxide-->Sulfuric acid-->Toluene-->Nitric acid-->4-Nitrotoluene
【Preparation Products】

o-Toluidine-->4-Nitrotoluene-->Indole-->2,6-Dichlorotoluene-->2,4-Dichlorotoluene-->3-Nitrotoluene-->2-(CYANOMETHYL)-BENZENESULFONAMIDE-->2-Nitrobenzaldehyde-->3-Chloro-2-methylaniline-->Quinclorac-->2,4-Dinitrotoluene-->4-Chloro-2-nitrotoluene-->2-Chloro-6-nitrotoluene-->Nifedipine-->5-chloro-2-methylbenzenediazonium-->Dibenz[b,f]azepine-5-carbonyl chloride-->Phenazine methosulfate-->5-Chloro-2-methylaniline-->Dicloxacillin sodium-->2-Nitrobenzoic acid-->2-Nitrobenzyl bromide-->2,6-Dinitrotoluene-->2-Nitrobenzyl alcohol-->Carbamazepine-->Iminodibenzyl
Hazard InformationBack Directory
[General Description]

Light yellow oily liquid with a characteristic odor of aromatic nitro compounds. Sinks in water. Derived from toluene by nitration and separation by fractional distillation. Flash point 223°F.
[Reactivity Profile]

O-NITROTOLUENE(88-72-2) is toxic by inhalation, ingestion and skin aborption, targeting the blood, central nervous system, skin, and gastrointestinal tract. Symptoms include, anoxia, weakness or dizziness, nausea and vomiting. If O-NITROTOLUENE(88-72-2) contacts the eye, the eye should be irrigated immediately. If O-NITROTOLUENE(88-72-2) contacts the skin, the area should be washed with soap. If inhaled, respiratory support should be administered. Finally, if ingested, medical attention should be sought. O-NITROTOLUENE(88-72-2) also reacts with sulfuric acid, sodium hydroxide, hydrogen, sodium, tetranitromethane, reducing agents and strong oxidizers. O-NITROTOLUENE(88-72-2) is very heat sensitive.
[Air & Water Reactions]

Insoluble in water.
[Hazard]

Toxic by inhalation, ingestion, skin absorption. Methemoglobinemia. Probable carcinogen.
[Health Hazard]

INHALATION, INGESTION, OR SKIN: Headache, flushing of face, dizziness, dyspnea (difficult breathing), cyanosis, nausea, vomiting, muscular weakness, increased pulse and respiratory rate, irritability, and convulsions. SKIN: Irritation.
[Potential Exposure]

The nitrotoluenes are used in the production of toluidines and other dye intermediates. All isomers are used in manufacture of agriculture and rubber chemicals and in various dyes.
[First aid]

If this chemical gets into the eyes, remove any contact lenses at once and irrigate immediately for at least 15 minutes, occasionally lifting upper and lower lids. Seek medical attention immediately. If this chemical contacts the skin, remove contaminated clothing and wash immediately with soap and water. Seek medical attention immediately. If this chemical has been inhaled, remove from exposure, begin rescue breathing (using universal precautions, including resuscitation mask) if breathing has stopped and CPR if heart action has stopped. Transfer promptly to a medical facility. When this chemical has been swallowed, get medical attention. Give large quantities of water and induce vomiting. Do not make an unconscious person vomit.
[Shipping]

UN1664 Nitrotoluenes, (o-; m-; p-), Hazard Class: 6.1; Labels: 6.1-Poisonous materials.
[Incompatibilities]

Decomposes on contact with strong oxidizers; strong acids; reducing agents; strong bases; ammonia, amines producing toxic fumes, causing fire and explosion hazard. Heat above 190C may cause explosive decomposition. Attacks some plastics, rubbers, and coatings.
[Waste Disposal]

Controlled incineration-care must be taken to maintain complete combustion at all times. Incineration of large quantities may require scrubbers to control the emission of nitrogen oxides.
Material Safety Data Sheet(MSDS)Back Directory
[msds information]

alpha-Methylnitrobenzene(88-72-2).msds
Questions And AnswerBack Directory
[Overview]

O-nitrotoluene is also known as 2-nitrotoluene or 1-methyl-2-nitrobenzene,and is yellow oily transparent liquid. It has the smell of nitrobenzene. The relative density is 1.1629. The melting point is-2.9℃ (α-type, stable type),-9.5℃ (β-type, non-stable type). The boiling point is 221.7 °C, 118 °C (2.133×103Pa) and 50.0 °C (0.133×103Pa). The flash point is 106.1 °C (closed system). The refractive index is 1.5450. The viscosity is 0.0262 mPa•s (15℃). The vapor pressure (×103 Pa) is 10.906 (5℃), 12.639 (10℃), 14.612 (20℃), 15.892 (30℃). It is slightly soluble in water (0.061 at 30°C), soluble in benzene, chloroform and petroleum ether and immiscible with ethanol and ether. It can evaporate together with water vapor. Due to the strong electron-withdrawing ability of nitro group, the methyl of is easy to be oxidized to form o-nitrobenzaldehyde or o-nitrobenzoic acid according to oxidation conditions. And o-nitrotoluene can be reduced in the presence of catalyst to generate o-toluidine, which can generate 2,4 or 2,6 dinitrotoluene after further nitration. O-nitrotoluene can also be chlorinated to generate nitrobenzyl chloride. In addition, o-nitrotoluene can also generate azo compounds. LD50 (rat oral) is 801mg/kg.
O-nitrotoluene is mainly used as the raw material of dyestuffs to prepare 4-chloro-2-nitrotoluene, 6-chloro-2-nitrotoluene, o-toluidine, o-tolidine, 2,6-dichlorobenzaldehyde and other dyestuffs intermediates, in which 4-chloro-2-nitrotoluene is a pharmaceutical raw material and o-toluidine is the raw material of pesticide fungicides and spices. O-nitrotoluene is a pharmaceutical raw material to prepare 2,2'-dinitrobenzene, o-nitrobenzyl bromide, bromine alkane and other medicines, and is also the raw material to prepare indole to be used as amino acids and plant growth regulators. O-nitrotoluene is the raw material to prepare dinitrotoluene to be used as powder. O-toluidine can also be used as vulcanization accelerator and to prepare o-nitrobenzoic acid as pharmaceutical raw material.
[Chemical Properties]

Yellow flammable liquid; insoluble in water; soluble in chloroform and benzene; immiscible with ethanol and ethyl ether.
[Application]

Used for the intermediates of dyes and pesticides, and also for the production of coatings, plastics and pharmaceuticals. O-nitrotoluene is mainly used in the production of o-toluidine, o-tolidine, and also used as the important raw materials of dyes, paints, plastics and pharmaceutical. In the pharmaceutical industry, it is used for the production of nifedipine, tegretol, imipramine hydrochloride, bromide has hydrochloride amine and sodium dicloxaeillin.I can also be used for dyes, pharmaceuticals, pesticides, plastics and other industries.
[Production method]

Nitrify toluene with mixed acid to generate mixed nitrotoluene, which mainly consists of o-nitrotoluene (about two-thirds) and p-nitrotoluene (about one-third). The mixed nitrotoluene can be separated to get the pure product. Add toluene to the reactor and cool to below 25℃. Then add the mixed acid (ie, 25-30% of nitric acid, 55-58% of sulfuric acid and 20-21% of water) and control the temperature not exceeding 50℃. Stir for 1-2h, and then stand for 6h. Separate the generated nitrotoluene, and wash them with water and alkali liquor to remove unreacted toluene and aliphatic compound. The crude nitrotoluene products consist of 55-60% of o-nitrotoluene, 2-5% of m-nitrotoluene and 35-40% of p-nitrotoluene, with a yield of 90-95%. The various isomers can be separated by crude distillation and crystallization according to the difference of the boiling point and melting point. Namely, first distill the crude nitrotoluene under vacuum to separate out the majority of o-nitrotoluene. And then the residual fraction containing more p-nitrotoluene is separated by vacuum distillation, and cooled for crystallization and separated to obtain the finished products. The tarry substance with high boiling point remains in the still. M-nitrotoluene remains in the mother liquor separated out the p-nitrotoluene, and can be obtained by rectification after repeated accumulation. The purity of ortho and para nitrotoluene can respectively reach 98% and 99%. The domestic process is the two-pot series process, and the reaction temperature of the main pot is 40-45℃ and the second pot is 50-55℃. The preparation of mixed acid is roughly similar, including 26-28% of nitric acid, 56-57% of sulfuric acid and 16-18% of water. The raw material consumption quota: toluene (98%) 800kg/t, nitric acid (98%) 470kg/t, sulfuric acid (92.5%) 450kg/t, caustic soda (42%) 100kg /t
[Category]

Toxic substance
[Toxicity classification]

moderate toxicity
[Acute toxicity]

Oral-Rat LD50: 891 mg/kg; Oral-mouse LD50: 970 mg/kg
[Explosives hazardous characteristics]

Explore when mixing with air; explore itself when meeting heat
[Flammability Hazardous properties]

Combust when meeting open fire; Combustion produces toxic nitrogen oxide fumes.
[Storage and transportation characteristics]

Stored in the low-temperature, well-ventilated and dry warehouse and stored separately with oxidants and food additives.
[Fire extinguishing agent]

mist water, foam, carbon dioxide
[Occupational Standard]

TWA 28 mg/m3; STEL 58 mg/m3
Spectrum DetailBack Directory
[Spectrum Detail]

2-Nitrotoluene(88-72-2) IR2
2-Nitrotoluene(88-72-2) 13C NMR
2-Nitrotoluene(88-72-2) IR1
2-Nitrotoluene(88-72-2) 1H NMR
2-Nitrotoluene(88-72-2) MS
2-Nitrotoluene(88-72-2) ESR
Well-known Reagent Company Product InformationBack Directory
[Acros Organics]

2-Nitrotoluene, 99+%(88-72-2)
[Alfa Aesar]

2-Nitrotoluene, 99+%(88-72-2)
[Sigma Aldrich]

88-72-2(sigmaaldrich)
[TCI AMERICA]

2-Nitrotoluene,>99.0%(GC)(88-72-2)
88-72-2 suppliers list
Company Name: Hefei TNJ Chemical Industry Co.,Ltd.
Tel: +86-0551-65418679
Fax: 86-0551-65418697
Website: www.tnjchem.com
Company Name: Shanxi Naipu Import and Export Co.,Ltd
Tel: +8613734021967
Fax:
Website: https://www.chemicalbook.com/manufacturer/Chisure/
Company Name: Xiamen AmoyChem Co., Ltd
Tel: +86 592-605 1114
Fax:
Website: www.amoychem.com
Company Name: Hubei xin bonus chemical co. LTD
Tel: 86-13657291602
Fax: 027-59338440
Website: www.chemicalbook.com/ShowSupplierProductsList1549548/0.htm
Company Name: Shandong chuangyingchemical Co., Ltd.
Tel: 18853181302
Fax:
Website: www.chemicalbook.com/ShowSupplierProductsList103425/0.htm
Company Name: Shanghai Longyu Biotechnology Co., Ltd.
Tel: +8615821988213
Fax: +86 15821988213
Website: https://www.chemicalbook.com/manufacturer/ExhibitionBooth164/
Company Name: HENAN BON INDUSTRIAL CO.,LTD
Tel: 0371-55170695
Fax:
Website: www.bonchemical.com
Company Name: CONIER CHEM AND PHARMA LIMITED
Tel: 86-18523575427
Fax:
Website: http://www.conier.com/
Company Name: career henan chemical co
Tel: 0086-371-86658258 , 13203830695
Fax: 0086-371-86658258
Website: www.coreychem.com
Company Name: Shaanxi Dideu Medichem Co. Ltd
Tel: 15319487004
Fax: 029-88380327
Website: www.chemicalbook.com/ShowSupplierProductsList715900/0.htm
Company Name: Richest Group Ltd
Tel: 18017061086
Fax:
Website: www.richest-oled.com
Company Name: Fuxin Pharmaceutical
Tel: 021-50872116
Fax:
Website: www.fuxinpharm.com
Company Name: Binhai henglian chemicals co. LTD
Tel: 025-86736270
Fax: 025-52279193
Website: www.henglianchem.com
Company Name: Neostar United (Changzhou) Industrial Co., Ltd.
Tel: +0086-519-85557386
Fax: +0086-519-85557389
Website: www.neostarunited.com
Company Name: SIMAGCHEM CORP
Tel: +86 13806087780 , 13806087780
Fax:
Website: www.simagchem.com
Company Name: Hefei TNJ Chemical Industry Co.,Ltd.
Tel: 0551-65418671
Fax: 0551-65418697
Website: https://www.tnjchem.com
Company Name: Anhui Rencheng Technology Co., Ltd
Tel: 16655163890
Fax:
Website: https://www.chemicalbook.com/manufacturer/ExhibitionBooth349/
Company Name: WinWin Chemical CO., Limited
Tel: 0086-577-64498589 , 15325081899
Fax: 0086-577-56994596
Website: www.win-winchemical.com
Tags:88-72-2 Related Product Information
824-39-5 60956-26-5 52414-97-8 610-14-0 612-25-9 552-16-9 1671-49-4 612-22-6 769-10-8 455-88-9 619-23-8 612-23-7 3958-57-4 570-24-1 115571-67-0 400-74-8 1427-07-2 446-33-3